Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, the Sahlgrenska Academy, SE-413 45 Gothenburg, Sweden.
Stroke. 2011 Jan;42(1):214-6. doi: 10.1161/STROKEAHA.110.594010. Epub 2010 Dec 9.
in a genome-wide association study and subsequent case-control studies, the single-nucleotide polymorphism rs12425791 on chromosome 12p13 was reported to be associated with ischemic stroke, but this could not be validated in a recent well-powered study. We therefore investigated whether an association between ischemic stroke and rs12425791 could be detected in 3 different case-control studies from the southwest of Sweden.
we examined 3606 patients with ischemic stroke and 2528 controls from 3 independent case-controls studies.
no significant association between ischemic stroke and the single-nucleotide polymorphism rs12425791 was detected in any of the 3 case-control samples or in the samples combined. The odds ratio for ischemic stroke for the minor allele in the combined sample was 1.02 (95% CI, 0.93 to 1.13).
the single-nucleotide polymorphism rs12425791 does not confer a substantial risk for ischemic stroke in our population. Our results support a recent large study including other European populations.
在全基因组关联研究及随后的病例对照研究中，位于 12 号染色体 12p13 上的单核苷酸多态性 rs12425791 被报道与缺血性脑卒中相关，但最近一项大型研究未能证实这一关联。因此，我们在瑞典西南部的 3 项不同的病例对照研究中，调查了 rs12425791 与缺血性脑卒中之间是否存在关联。
我们检测了来自 3 项独立病例对照研究的 3606 例缺血性脑卒中患者和 2528 例对照。
在 3 项病例对照样本或合并样本中，均未发现缺血性脑卒中与单核苷酸多态性 rs12425791 之间存在显著关联。合并样本中，缺血性脑卒中患者携带较少等位基因的比值比为 1.02（95%可信区间，0.93 至 1.13）。
在我们的人群中，单核苷酸多态性 rs12425791 并未显著增加缺血性脑卒中的风险。我们的结果支持最近一项包括其他欧洲人群的大型研究。
