Enticott J C, Eastwood H T, Briggs R J, Dowell R C, O'Leary S J
Department of Otolaryngology, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne Cochlear Implant Clinic, Vic., Australia.
Audiol Neurootol. 2011;16(5):289-303. doi: 10.1159/000322137. Epub 2010 Dec 11.
This prospective, double-blind controlled, randomized clinical trial of 43 adults showed that topical methylprednisolone applied to the round window during cochlear implantation was effective in protecting inner ear function. Postoperative vestibular disturbance was significantly lower in the steroid group (5%) than the control group (29%). Electrode impedances from the middle portion of the electrode array (electrodes 10-13) were significantly reduced in steroid-treated recipients compared to controls. Hearing and vestibular function analyses were under-powered to detect any drug changes due to limited participant data.
这项针对43名成年人的前瞻性、双盲对照、随机临床试验表明，在人工耳蜗植入期间将局部用甲基强的松龙应用于圆窗对保护内耳功能有效。类固醇组术后前庭功能障碍（5%）显著低于对照组（29%）。与对照组相比，类固醇治疗的受试者电极阵列中部（电极10 - 13）的电极阻抗显著降低。由于参与数据有限，听力和前庭功能分析检测任何药物变化的效能不足。
