Abe Y, Hasegawa Y, Miyamoto K, Yamaguchi M, Andoh A, Ibuki Y, Igarashi M
Department of Obstetrics and Gynecology, Gunma University School of Medicine, Maebashi, Japan.
J Clin Endocrinol Metab. 1990 Jul;71(1):133-7. doi: 10.1210/jcem-71-1-133.
The plasma inhibin concentrations in 190 normal pregnant women at 5-40 weeks gestation and in 4 puerperal women were measured by a specific RIA for human inhibin. The average plasma inhibin concentrations in pregnant women throughout pregnancy (minimum, 2.25 +/- 0.48 IU/mL at 17 weeks gestation; maximum, 24.15 +/- 6.99 IU/mL at 39 weeks gestation) were much higher than those in nonpregnant women with a normal menstrual cycle (0.46 +/- 0.04 IU/mL in the midfollicular phase and 2.02 +/- 0.47 IU/mL in the midluteal phase). The inhibin concentrations were already high at 5 weeks gestation (7.54 +/- 1.10 IU/mL) and rose to peak at 8-10 weeks gestation. The concentrations then decreased and remained relatively low during 14-30 weeks gestation, but rose again during the third trimester. The inhibin concentrations decreased to undetectable levels after delivery. Immunoreactive inhibin was demonstrated in the corpus luteum and term placental extracts, and the dose-response curves were parallel to an inhibin preparation from human follicular fluid. Immunoreactive inhibin concentrations were also high in both the umbilical vein and artery (7.77 +/- 0.80 and 7.84 +/- 0.78 IU/mL, respectively). These observations suggest that both the corpus luteum and placenta are likely sources of inhibin.
采用人抑制素特异性放射免疫分析法（RIA）测定了190例孕龄5 - 40周的正常孕妇及4例产后妇女血浆抑制素浓度。孕妇整个孕期血浆抑制素平均浓度（最低值：孕17周时为2.25±0.48 IU/mL；最高值：孕39周时为24.15±6.99 IU/mL）远高于月经周期正常的非孕妇（卵泡中期为0.46±0.04 IU/mL，黄体中期为2.02±0.47 IU/mL）。抑制素浓度在孕5周时已较高（7.54±1.10 IU/mL），并在孕8 - 10周时升至峰值。随后浓度下降，在孕14 - 30周期间维持在相对较低水平，但在孕晚期又再次升高。产后抑制素浓度降至检测不到的水平。在黄体和足月胎盘提取物中均检测到免疫反应性抑制素，且剂量 - 反应曲线与来自人卵泡液的抑制素制剂平行。脐静脉和脐动脉中的免疫反应性抑制素浓度也较高（分别为7.77±0.80和7.84±0.78 IU/mL）。这些观察结果表明，黄体和胎盘可能都是抑制素的来源。
