Department of Neurology, Girona Biomedical Research Institute (IdiBGi), Dr. Josep Trueta University Hospital, Av de França s/n, 17007 Girona, Spain.
Molecules. 2010 Dec 10;15(12):9104-34. doi: 10.3390/molecules15129104.
It is important to understand the molecular mechanisms underlying neuron death following stroke in order to develop effective neuroprotective strategies. Since studies on human stroke are extremely limited due to the difficulty in collecting post-mortem tissue at different time points after the onset of stroke, brain ischaemia research focuses on information derived from in-vitro models of neuronal death through ischaemic injury [1]. This review aims to provide an update on the different in-vitro stroke models with brain microvascular endothelial cells that are currently being used. These models provide a physiologically relevant tool to screen potential neuroprotective drugs in stroke and to study the molecular mechanisms involved in brain ischaemia.
为了开发有效的神经保护策略,了解中风后神经元死亡的分子机制非常重要。由于由于中风发作后不同时间点采集死后组织非常困难,因此对人类中风的研究极为有限,因此脑缺血研究侧重于通过缺血损伤从体外神经元死亡模型中获得的信息[1]。本综述旨在提供当前使用的具有脑微血管内皮细胞的不同体外中风模型的最新信息。这些模型为筛选中风中潜在的神经保护药物以及研究脑缺血涉及的分子机制提供了一种生理相关的工具。