Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Oncogene. 2011 Apr 21;30(16):1851-4. doi: 10.1038/onc.2010.573. Epub 2010 Dec 13.
One hallmark of cancer is intrinsic or acquired resistance to apoptosis. Surprisingly, recent studies demonstrate that CD95/Fas/Apo1 and p53 upregulated mediator of apoptosis/PUMA (potent inducers of the death receptor and the mitochondrial apoptotic pathways, respectively) promote tumorigenesis. These findings provide important insights into the multifaceted roles of apoptosis in tumorigenesis.
癌症的一个标志是内在或获得性的细胞凋亡抵抗。令人惊讶的是，最近的研究表明，CD95/Fas/Apo1 和 p53 上调凋亡介体/PUMA（分别为死亡受体和线粒体凋亡途径的有效诱导剂）促进肿瘤发生。这些发现为细胞凋亡在肿瘤发生中的多方面作用提供了重要的见解。
