一种与免疫球蛋白E盒结合蛋白相关的螺旋-环-螺旋蛋白。
A helix-loop-helix protein related to the immunoglobulin E box-binding proteins.
作者信息
Carr C S, Sharp P A
机构信息
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.
出版信息
Mol Cell Biol. 1990 Aug;10(8):4384-8. doi: 10.1128/mcb.10.8.4384-4388.1990.
Abstract
A human cDNA encoding a novel protein in the helix-loop-helix family has been isolated by screening a bacteriophage expression library with a probe containing the binding site for major late transcription factor. The protein encoded by this cDNA, TFEB, probably recognizes E-box sequences in the heavy-chain immunoglobulin enhancer.
摘要
通过用包含主要晚期转录因子结合位点的探针筛选噬菌体表达文库，分离出了一种编码螺旋-环-螺旋家族新蛋白的人类cDNA。该cDNA编码的蛋白TFEB可能识别重链免疫球蛋白增强子中的E-box序列。
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