巴基斯坦人群中谷胱甘肽S-转移酶GSTT1和GSTM1基因多态性与假性剥脱性青光眼的关联。
The association of glutathione S-transferase GSTT1 and GSTM1 gene polymorphism with pseudoexfoliative glaucoma in a Pakistani population.
作者信息
Khan Muhammad Imran, Micheal Shazia, Akhtar Farah, Ahmed Waqar, Ijaz Bushra, Ahmed Asifa, Qamar Raheel
机构信息
Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan.
出版信息
Mol Vis. 2010 Oct 26;16:2146-52.
PURPOSE
The aim of the present study was to investigate the association of glutathione S-transferase GSTT1 and GSTM1 genotypes with pseudoexfoliative glaucoma (PEXG) in a group of Pakistani patients.
METHODS
Multiplex polymerase chain reaction was used to study the GSTT1 and GSTM1 polymorphisms in 165 PEXG patients and 162 unaffected controls.
RESULTS
In the current study we describe a significant gender-specific association of GSTT1 and GSTM1 null genotypes with PEXG. The three null genotype combinations (i.e., T1M0, T0M1, and T0M0) were found at significantly higher frequencies in the PEXG patients as compared to the controls (χ(2)=21.82, p<0.001). This association was specifically related to the female patients (χ(2)=35.63, p<0.001); no such association was seen in the male patients (χ(2)=2.28, p>0.05).
CONCLUSIONS
The results suggest that there is a significant involvement of the GSTT1 and GSTM1 polymorphisms in female Pakistani patients having PEXG, which suggests a possible gender-specific impairment of detoxification in this group.
目的
本研究旨在调查一组巴基斯坦患者中谷胱甘肽S-转移酶GSTT1和GSTM1基因多态性与假性剥脱性青光眼（PEXG）之间的关联。
方法
采用多重聚合酶链反应研究165例PEXG患者和162例未受影响对照者的GSTT1和GSTM1基因多态性。
结果
在本研究中，我们描述了GSTT1和GSTM1无效基因型与PEXG之间存在显著的性别特异性关联。与对照组相比，三种无效基因型组合（即T1M0、T0M1和T0M0）在PEXG患者中的出现频率显著更高（χ(2)=21.82，p<0.001）。这种关联与女性患者特别相关（χ(2)=35.63，p<0.001）；男性患者中未观察到这种关联（χ(2)=2.28，p>0.05）。
结论
结果表明，GSTT1和GSTM1基因多态性在患有PEXG的巴基斯坦女性患者中显著参与，这表明该组可能存在性别特异性的解毒功能损害。
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