Agius Lawrence M
27 "Ballarat", Guzeppe Caruana Str., Tal-Virtu, Rabat RBT09, Malta.
Patholog Res Int. 2010;2010:509245. doi: 10.4061/2010/509245. Epub 2009 Oct 12.
The provision of dynamic splicing events constitutes the reflected nature of neoplasia that locally infiltrates and systemically spreads in terms of evolutionary attributes of the primary and various secondary pathways in malignant transformation. The significant diversity in molecular characterization of the given tumor lesion would adaptively conform to dynamics of splicing as enhanced or silenced exons of the premessenger RNA molecule. The proteins synthesized are in turn potential modifiers in further gene expression within such contexts as RNA:protein and RNA:DNA binding events. The recognition of pathways of incremental scope would underline the development of lesions, such as tumors, as multiple alternative splicing phenomena primarily affecting molecular physicochemical identity. It is within contexts of operative intervention and modification that the real identity of the malignant neoplastic process arises, within terms of reference of contextual splicing events. Disrupted gene expression is thus a referential pathway in the modification of splicing that may prove constitutive or alternative, in first instance, but also aberrant as the lesion progresses locally and systemically.
动态剪接事件的发生构成了肿瘤形成的反映性本质，就恶性转化中主要和各种次要途径的进化属性而言，肿瘤会在局部浸润并在全身扩散。特定肿瘤病变分子特征的显著多样性会适应性地顺应剪接动态，即前体信使RNA分子中外显子的增强或沉默。所合成的蛋白质进而会在诸如RNA:蛋白质和RNA:DNA结合事件等背景下成为进一步基因表达的潜在调节因子。对范围不断扩大的途径的认识将突显病变（如肿瘤）的发展，即主要影响分子物理化学特性的多种可变剪接现象。正是在手术干预和修饰的背景下，恶性肿瘤形成过程的真实本质才会在上下文剪接事件的参考范围内显现出来。因此，基因表达失调是剪接修饰中的一条参考途径，最初可能是组成性或选择性的，但随着病变在局部和全身的进展也会出现异常。
