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参附注射液预处理抑制糖尿病大鼠心肌缺血再灌注损伤：通过PI3K/Akt途径激活内皮型一氧化氮合酶

Shen-Fu injection preconditioning inhibits myocardial ischemia-reperfusion injury in diabetic rats: activation of eNOS via the PI3K/Akt pathway.

作者信息

Wu Yang, Xia Zhong-yuan, Meng Qing-tao, Zhu Jie, Lei Shaoqing, Xu Jinjin, Dou Juan

机构信息

Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.

出版信息

J Biomed Biotechnol. 2011;2011:384627. doi: 10.1155/2011/384627. Epub 2010 Nov 29.

DOI:10.1155/2011/384627
PMID:21151615
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2997576/
Abstract

The aim of this paper is to investigate whether Shen-fu injection (SFI), a traditional Chinese medicine, could attenuate myocardial ischemia-reperfusion (MI/R) injury in diabetes. Streptozotocin-induced diabetic rats were randomly assigned to the Sham, I/R, SFI preconditioning, and SFI plus wortmannin (a phosphatidylinositol 3-kinase inhibitor) groups. After the treatment, hearts were subjected to 30 min of coronary artery occlusion and 2 h reperfusion except the Sham group. Myocardial infarct size and cardiomyocytes apoptosis were increased significantly in MI/R group as compared with the Sham group. SFI preconditioning significantly decreased infarct size, apoptosis, caspase-3 protein expression, MDA level in myocardial tissues, and plasma level of CK and LDH but increased p-Akt, p-eNOS, bcl-2 protein expression, and SOD activity compared to I/R group. Moreover, SFI-induced cardioprotection was abolished by wortmannin. We conclude that SFI preconditioning protects diabetic hearts from I/R injury via PI3K/Akt-dependent pathway.

摘要

本文旨在研究中药参附注射液（SFI）是否能减轻糖尿病心肌缺血再灌注（MI/R）损伤。将链脲佐菌素诱导的糖尿病大鼠随机分为假手术组、I/R组、SFI预处理组和SFI加渥曼青霉素（一种磷脂酰肌醇3激酶抑制剂）组。处理后，除假手术组外，心脏进行30分钟冠状动脉闭塞和2小时再灌注。与假手术组相比，MI/R组心肌梗死面积和心肌细胞凋亡显著增加。与I/R组相比，SFI预处理显著减小梗死面积、凋亡、心肌组织中caspase-3蛋白表达、MDA水平以及血浆CK和LDH水平，但增加了p-Akt、p-eNOS、bcl-2蛋白表达和SOD活性。此外，渥曼青霉素消除了SFI诱导的心脏保护作用。我们得出结论，SFI预处理通过PI3K/Akt依赖性途径保护糖尿病心脏免受I/R损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38a4/2997576/71712d06cb5c/JBB2011-384627.008.jpg
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