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利用硝酸铈铵合成四取代吡唑的简便方法。

Facile Route to Tetrasubstituted Pyrazoles Utilizing Ceric Ammonium Nitrate.

作者信息

Devery James J, Mohanta Pramod K, Casey Brian M, Flowers Robert A

机构信息

Department of Chemistry, Lehigh University, Bethlehem, PA 18015, USA.

出版信息

Synlett. 2009(9):1490-1494. doi: 10.1055/s-0029-1217163.

DOI:10.1055/s-0029-1217163
PMID:21151843
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2998890/
Abstract

A convenient approach for the synthesis of tetrasubstituted pyrazoles is described. The method involves the treatment of 1,3-diketones and allyltrimethylsilane with CAN followed by cerium-catalyzed addition of substituted hydrazines to construct pyrazoles in good yields.

摘要

本文描述了一种合成四取代吡唑的简便方法。该方法包括用硝酸铈铵处理1,3 - 二酮和烯丙基三甲基硅烷，然后通过铈催化的取代肼加成反应，以良好的产率构建吡唑。

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