二尖瓣反流患者N末端B型利钠肽原与超声心动图指标的比较。
Comparison of N-terminal pro B-natriuretic Peptide and echocardiographic indices in patients with mitral regurgitation.
作者信息
Hajsadeghi Shokoufeh, Samiei Niloufar, Moradi Masoud, Majid Maleki, Kashani Ladan, Amani Afsaneh, Salami Arezoo, Asefi Melika, Farsi Negin
机构信息
Rasoul Akram Medical Centre, Tehran, Islamic Republic of Iran.
出版信息
Clin Med Insights Cardiol. 2010 Nov 30;4:111-6. doi: 10.4137/CMC.S6062.
INTRODUCTION
Echocardiographic indices can form the basis of the diagnosis of systolic and diastolic left ventricular (LV) dysfunction in patients with Mitral regurgitation (MR). However, using echocardiography alone may bring us to a diagnostic dead-end. The aim of this study was to compare N-Terminal pro B-natriuretic peptide (BNP) and echocardiographic indices in patients with mitral regurgitation.
METHODS
2D and Doppler echocardiography and BNP serum level were obtained from 54 patients with organic mild, moderate and severe MR.
RESULTS
BNP LEVELS WERE INCREASED WITH SYMPTOMS IN PATIENTS WITH MITRAL REGURGITATION (NYHAI: 5.7 ± 1.1, NYHAII: 6.9 ± 1.5, NYHAIII: 8.3 ± 2 pg/ml, P < 0.001). BNP plasma level were significantly correlated with MPI (myocardial performance index) (r = 0.399, P = 0.004), and following echocardiographic indices: LVEDV (r = 0.45, P < 0.001), LVESV (r = 0.54, P < 0.001), LVEDD (r = 0.48, P < 0.001), LVESD (r = 0.54, P < 0.001), dp/dt (r = -0.32, P = 0.019) and SPAP (r = 0.4, P = 0.006).
CONCLUSION
The present study showed that BNP may be useful in patients with MR and may confirm echocardiographic indices.
引言
超声心动图指标可作为二尖瓣反流（MR）患者左心室收缩和舒张功能障碍诊断的基础。然而，仅使用超声心动图可能会使我们陷入诊断僵局。本研究的目的是比较二尖瓣反流患者的N末端B型利钠肽原（BNP）和超声心动图指标。
方法
对54例患有器质性轻度、中度和重度MR的患者进行二维和多普勒超声心动图检查以及BNP血清水平检测。
结果
二尖瓣反流患者的BNP水平随症状加重而升高（纽约心脏协会心功能分级I级：5.7±1.1，II级：6.9±1.5，III级：8.3±2 pg/ml，P<0.001）。BNP血浆水平与心肌做功指数（MPI）显著相关（r=0.399，P=0.004），并与以下超声心动图指标相关：左心室舒张末期容积（LVEDV，r=0.45，P<0.001）、左心室收缩末期容积（LVESV，r=0.54，P<0.001）、左心室舒张末期内径（LVEDD，r=0.48，P<0.001）、左心室收缩末期内径（LVESD，r=0.54，P<0.001）、dp/dt（r=-0.32，P=0.019）和肺动脉收缩压（SPAP，r=0.4，P=0.006）。
结论
本研究表明，BNP可能对二尖瓣反流患者有用，并可证实超声心动图指标。
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