酒精戒断点燃现象：抗惊厥药物能发挥作用吗？
Alcohol withdrawal kindling: is there a role for anticonvulsants?
作者信息
Modesto-Lowe Vania, Huard Jessica, Conrad Cynthia
机构信息
Dr. Modesto-Lowe is Assistant Professor and Dr. Conrad is Associate Professor from the Department of Psychiatry, University of Connecticut School of Medicine and both are from Connecticut Valley Hospital; Ms. Huard is Master's Physician Assistant Student, Quinnipiac University-All from Middletown, Connecticut.
出版信息
Psychiatry (Edgmont). 2005 May;2(5):25-31.
Animal and clinical studies supporting the kindling hypothesis of alcohol withdrawal suggest the need to revisit current treatment concepts. While traditional approaches have emphasized symptom reduction and prevention of complications, novel approaches include slowing progress of clinical severity associated with multiple withdrawals. Currently, it is unclear if medications can halt cumulative neurotoxicity associated with multiple withdrawals. However, the ability of anticonvulsants to improve the course of alcohol withdrawal and their neuroprotective effects may be of interest. The use of anticonvulsants as probes in animal models of kindling and controlled trials examining the efficacy of newer anticonvulsants in the treatment of alcohol withdrawal may improve understanding of alcohol withdrawal kindling and its treatment.
支持酒精戒断点燃假说的动物和临床研究表明，有必要重新审视当前的治疗理念。虽然传统方法强调症状减轻和并发症预防，但新方法包括减缓与多次戒断相关的临床严重程度进展。目前，尚不清楚药物是否能阻止与多次戒断相关的累积神经毒性。然而，抗惊厥药改善酒精戒断病程的能力及其神经保护作用可能值得关注。在点燃动物模型中使用抗惊厥药作为探针，并进行对照试验以检验新型抗惊厥药治疗酒精戒断的疗效，可能会增进对酒精戒断点燃及其治疗的理解。
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