Centre for Surface Chemistry and Catalysis, Katholieke Universiteit Leuven, Kasteelpark Arenberg 23, BE-3001 Heverlee, Belgium.
Phys Chem Chem Phys. 2011 Feb 21;13(7):2706-13. doi: 10.1039/c0cp01640c. Epub 2010 Dec 10.
The purpose of this study was to improve our understanding of the molecular organization of hydrophobic guest molecules in the presence of co-adsorbed water inside SBA-15 ordered mesoporous silica material. Understanding this adsorption competition is essential in the development of applications of controlled adsorption and desorption. The poorly water soluble drug compound itraconazole and the fluorescent probe Nile red were selected for the study. The interaction between itraconazole and SBA-15 was investigated using FT-IR, (1)H MAS NMR and (29)Si MAS NMR spectroscopy, by determination of adsorption isotherms and release kinetics in simulated gastric fluid. The distribution and migration of the hydrophobic fluorescent probe Nile red was visualized in situ using confocal fluorescence microscopy. For both molecules, there was a pronounced influence of the co-adsorbed water on adsorption, hydrophobic aggregation and migration in SBA-15 pores. These insights contribute to the development of practical methods for loading ordered mesoporous silica materials with hydrophobic molecules.
本研究旨在增进我们对于疏水分子在 SBA-15 有序介孔硅材料中存在共吸附水时的分子组织的理解。理解这种吸附竞争对于控制吸附和解吸的应用的发展至关重要。选择疏水性差的药物化合物伊曲康唑和荧光探针尼罗红进行研究。通过测定在模拟胃液中的吸附等温线和释放动力学，使用傅立叶变换红外光谱（FT-IR）、（1）H MAS NMR 和（29）Si MAS NMR 光谱学研究伊曲康唑与 SBA-15 之间的相互作用。使用共聚焦荧光显微镜原位可视化疏水性荧光探针尼罗红的分布和迁移。对于这两种分子，共吸附水对吸附、疏水性聚集和在 SBA-15 孔中的迁移都有显著的影响。这些见解有助于开发将疏水分子载入有序介孔硅材料的实用方法。
