Department of Zoology, Biochemistry and Molecular Biology Laboratory, Banaras Hindu University, Varanasi, India.
Cell Mol Neurobiol. 2011 Apr;31(3):401-5. doi: 10.1007/s10571-010-9631-8. Epub 2010 Dec 9.
The allelic variant of apolipoprotein (Apo) E4 is a known risk factor for the development of most common late onset form of Alzheimer's disease (AD). As aging is associated with reduced circulating level of gonadal steroid hormones, hormone replacement therapies have been used for the possible treatment of AD. Both estrogen and testosterone have beneficial effects on brain due to interaction with apoE, but the underlying mechanism is still not clear. In this article, we report the effects of gonadectomy and hormone supplementation on apoE protein level in male and female mouse cerebral cortex during normal aging. We could not get any effect of gonadectomy and estradiol or testosterone treatment in adult and old mice of either sex. This suggests that during normal aging apoE protein level is not affected due to steroid hormone withdrawal or supplementation in the mouse cerebral cortex.
载脂蛋白（Apo）E4 的等位基因变体是大多数常见的迟发性阿尔茨海默病（AD）发展的已知风险因素。随着年龄的增长，循环中的性腺类固醇激素水平降低，因此激素替代疗法已被用于 AD 的可能治疗。由于与 apoE 的相互作用，雌激素和睾酮对大脑都有有益的影响，但潜在的机制尚不清楚。在本文中，我们报告了去势和激素补充对正常衰老过程中雄性和雌性小鼠大脑皮质中 apoE 蛋白水平的影响。我们在两性成年和老年小鼠中均未观察到去势、雌二醇或睾酮处理的任何作用。这表明，在正常衰老过程中，由于类固醇激素的去除或补充，小鼠大脑皮质中的 apoE 蛋白水平不受影响。
