Blaschuk O W, Munro S B, Farookhi R
Division of Urology, Department of Surgery, McGill University, Royal Victoria Hospital, 687 Pine Avenue West, H3A 1A1, Montreal, Quebec, Canada.
Endocrine. 1995 Feb;3(2):83-9. doi: 10.1007/BF02990057.
The cadherins are a family of calcium-dependent cell adhesion molecules which are thought to be key regulators of morphogenesis. This review contains a discussion of the structure, function and regulation of these cell adhesion molecules. In particular, we discuss recent studies that demonstrate the ability of steroids to modulate cadherin levelsin vivo. We speculate that steroids and estrogenic organochlorines exert their diverse morphoregulatory actions on tissues by altering cadherin levels.
钙黏蛋白是一类依赖钙的细胞黏附分子家族，被认为是形态发生的关键调节因子。本综述讨论了这些细胞黏附分子的结构、功能和调节。特别是，我们讨论了最近的研究，这些研究证明了类固醇在体内调节钙黏蛋白水平的能力。我们推测，类固醇和雌激素有机氯通过改变钙黏蛋白水平对组织发挥其多样的形态调节作用。
