Villanueva-Peñacarrillo M L, Delgado E, Vicent D, Mérida E, Alcántara A I, Valverde I
Departamento de Metabolismo, Nutrición y Hormonas, Fundación Jiménez Díaz, Avda. Reyes Católicos, 2. 28040, Madrid, Spain.
Endocrine. 1995 Sep;3(9):685-7. doi: 10.1007/BF02746345.
A higher specific binding of GLP-1(7-36)amide is found in skeletal muscle plasma membranes from adult streptozotocin (STZ)-treated rats (insulin-dependent diabetes mellitus model) and from neonatal STZ-treated rats (non insulin-dependent diabetes mellitus model), as compared to that in normal controls; no apparent change in the affinity was observed, that indicating the presence in both diabetic models of an increased number of high affinity binding sites for the peptide. The maximal specific GLP-1(7-16)amide binding in the non insulin-dependent diabetes mellitus model was found to be significantly higher than that in the insulin-dependent diabetes mellitus model. As GLP-1(7-36)amide exerts a glycogenic effect in the rat skeletal muscle, the present data suggest that the action of the peptide in the muscle glucose metabolism may be increased in states of insulin deficiency accompanied or not by insulin resistance.
与正常对照组相比，在成年链脲佐菌素（STZ）处理的大鼠（胰岛素依赖型糖尿病模型）和新生STZ处理的大鼠（非胰岛素依赖型糖尿病模型）的骨骼肌质膜中发现了更高的GLP-1(7-36)酰胺特异性结合；未观察到亲和力有明显变化，这表明在两种糖尿病模型中该肽的高亲和力结合位点数量增加。发现非胰岛素依赖型糖尿病模型中的最大特异性GLP-1(7-16)酰胺结合显著高于胰岛素依赖型糖尿病模型。由于GLP-1(7-36)酰胺在大鼠骨骼肌中发挥糖原生成作用，目前的数据表明，在伴有或不伴有胰岛素抵抗的胰岛素缺乏状态下，该肽在肌肉葡萄糖代谢中的作用可能会增强。
