受刺激的血小板会释放β淀粉样蛋白前体。
Stimulated platelets release amyloid beta-protein precursor.
作者信息
Cole G M, Galasko D, Shapiro I P, Saitoh T
机构信息
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093.
出版信息
Biochem Biophys Res Commun. 1990 Jul 16;170(1):288-95. doi: 10.1016/0006-291x(90)91272-t.
Abstract
Human platelets can be stimulated by thrombin or ionomycin to secrete soluble truncated amyloid beta-protein precursor and particulate membrane fragments which contain C-terminal and N-terminal immunoreactive amyloid beta-protein precursor. This suggests a possible circulating source of beta-protein in serum which may play a role in the formation of amyloid deposits. The release of soluble amyloid beta-protein precursor could be involved in normal platelet physiology.
摘要
人血小板可被凝血酶或离子霉素刺激，从而分泌可溶性截短淀粉样β蛋白前体和包含C端及N端免疫反应性淀粉样β蛋白前体的颗粒状膜片段。这表明血清中β蛋白可能存在循环来源，其可能在淀粉样沉积物的形成中发挥作用。可溶性淀粉样β蛋白前体的释放可能与正常血小板生理功能有关。
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