Penn State Hershey Eye Center, 500 University Drive, HU19, Hershey, PA 17033-0850, USA.
Adv Ther. 2011 Jan;28(1):40-50. doi: 10.1007/s12325-010-0088-4. Epub 2010 Dec 9.
Retinal vein occlusions are common retinal vascular disorders with the potential for significant vision-related morbidity. Retinal vein occlusions are classified as either branch retinal vein occlusion (BRVO), central retinal vein occlusion (CRVO), or hemiretinal vein occlusion (HRVO) based on the specific occlusion site. Decreased vision in patients afflicted with CRVO may result from retinal ischemia and/or the accumulation of fluid within the center of the retina (macular edema). The Central Vein Occlusion Study (CVOS) Group demonstrated that grid laser photocoagulation is not an effective treatment for decreased vision due to CRVO-related macular edema. Since publication of that report, the standard of care for patients with decreased vision due to CRVO-associated macular edema was observation. However, in the past 5 years, several major randomized controlled clinical trials have investigated new therapeutic modalities for the treatment of macular edema secondary to CRVO. This article aims to provide insight into current evidence-based approaches to the management of macular edema secondary to CRVO. A companion article reviews approaches for the management of macular edema secondary to BRVO.
视网膜静脉阻塞是常见的视网膜血管疾病，有导致严重视力相关发病率的潜力。视网膜静脉阻塞根据特定的阻塞部位分为分支视网膜静脉阻塞 (BRVO)、中央视网膜静脉阻塞 (CRVO) 或半侧视网膜静脉阻塞 (HRVO)。CRVO 患者的视力下降可能是由于视网膜缺血和/或视网膜中央（黄斑水肿）积液积聚所致。中央静脉阻塞研究 (CVOS) 小组表明，格栅激光光凝对于因 CRVO 相关黄斑水肿导致的视力下降并不是一种有效的治疗方法。自该报告发表以来，CRVO 相关性黄斑水肿导致视力下降的患者的标准治疗方法是观察。然而，在过去 5 年中，几项主要的随机对照临床试验已经研究了治疗 CRVO 继发黄斑水肿的新治疗方法。本文旨在提供对 CRVO 继发黄斑水肿治疗的循证方法的深入了解。一篇配套文章回顾了 BRVO 继发黄斑水肿的治疗方法。
