Department of Neurology, Yokosuka Kyosai Hospital, 1-16, Yonegahama-dori, Yokosuka, Kanagawa, 238-8558, Japan.
Neurol Sci. 2011 Apr;32(2):317-9. doi: 10.1007/s10072-010-0455-6. Epub 2010 Dec 11.
A 37-year-old woman suffered from sudden hemiparesis due to an ischemic stroke. Physical examination revealed dysmorphic features, cognitive impairment, and emotional lability. Radiological studies showed multiple intracranial arterial stenoses, and laboratory examination revealed diabetes mellitus, dyslipidemia, and endocrinological abnormalities consistent with secondary amenorrhea. Karyotyping disclosed partial monosomy of the short arm of the X chromosome. We diagnosed the patient with Turner syndrome and concluded that premature atherosclerosis was a cause of stroke. We emphasize a possible relationship between strokes and Turner syndrome. Physicians need to manage adult Turner patients carefully, especially with regard to metabolic dysfunctions, to prevent strokes.
一位 37 岁女性因缺血性脑卒中突发偏瘫。体格检查发现其存在畸形特征、认知障碍和情绪不稳定。影像学研究显示颅内多处动脉狭窄，实验室检查显示糖尿病、血脂异常和继发闭经的内分泌异常。核型分析显示 X 染色体短臂部分单体。我们诊断该患者为特纳综合征，并认为早发性动脉粥样硬化是卒中的一个病因。我们强调了卒中与特纳综合征之间可能存在的联系。医生需要仔细管理特纳综合征的成年患者，特别是针对代谢功能障碍，以预防卒中。
