Department of Oncology, Radiumhemmet, Karolinska University Hospital and Karolinska Institutet, 171 76 Stockholm, Sweden.
Breast Cancer Res Treat. 2012 Oct;135(3):791-8. doi: 10.1007/s10549-010-1283-3. Epub 2010 Dec 14.
To evaluate true acupuncture to control acupuncture (CTRL) (non-insertive stimulation at non-acupuncture points) in breast cancer patients treated with adjuvant tamoxifen suffering from hot flushes and sweatings. Eighty-four patients were randomized to receive either true acupuncture or CTRL twice a week for 5 weeks. Seventy-four patients were treated according to the protocol. In the true acupuncture group 42% (16/38) reported improvements in hot flushes after 6 weeks compared to 47% (17/36) in the CTRL group (95% CI, -28 to 18%). Both groups reported improvement regarding severity and frequencies in hot flushes and sweatings but no statistical difference was found between the groups. In a subanalysis regarding the severity of sweatings at night a statistically significant difference P = 0.03 was found in the true acupuncture group. Former experience of true acupuncture did not influence the perception of true acupuncture or CTRL. No significant differences in hormonal levels were found before and after treatment. In conclusion, convincing data that true acupuncture is more effective than CTRL in reducing vasomotor symptoms is still lacking. Our study shows that both true and CTRL reduce vasomotor symptoms in breast cancer patients treated with adjuvant tamoxifen.
评价真针刺（对照组：非穴位的非针刺性刺激）对接受辅助他莫昔芬治疗且伴有热潮红和出汗的乳腺癌患者的控制作用。84 名患者被随机分为真针刺组或对照组，每周接受 2 次治疗，共 5 周。74 名患者按照方案进行了治疗。在真针刺组中，6 周后有 42%（16/38）的患者报告热潮红症状改善，而对照组为 47%（17/36）（95%CI：-28 至 18%）。两组均报告热潮红和出汗的严重程度和频率有所改善，但组间无统计学差异。在针对夜间出汗严重程度的亚分析中，真针刺组的 P 值为 0.03，差异具有统计学意义。真针刺的既往经验并不影响对真针刺和对照组的感知。治疗前后激素水平无显著差异。总之，仍缺乏真针刺比对照组更有效地减少血管舒缩症状的确凿数据。我们的研究表明，真针刺和对照组均能减轻接受辅助他莫昔芬治疗的乳腺癌患者的血管舒缩症状。
