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舒张性心力衰竭的治疗。

Management of diastolic heart failure.

机构信息

3rd Department and Clinical Ward of Cardiology, Poland.

出版信息

Cardiol J. 2010;17(6):558-65.

Abstract

Diastolic heart failure (HF) is also referred to as HF with preserved left ventricular systolic function. The distinction between systolic and diastolic HFs is a pathophysiological one and isolated forms of left ventricular dysfunction are rarely observed. In diastolic HF left ventricular systolic function is normal or only slightly impaired, and the typical manifestations of HF result from increased filling pressure caused by impaired relaxation and compliance of the left ventricle. The predisposing factors for diastolic dysfunction include elderly age, female sex, obesity, coronary artery disease, hypertension and diabetes mellitus. Treatment of diastolic HF is aimed to stop the progression of the disease, relieve its symptoms, eliminate exacerbations and reduce the mortality. The management should include antihypertensive treatment, maintenance of the sinus rhythm, prevention of tachycardia, venous pressure reduction, prevention of myocardial ischemia and prevention of diabetes mellitus. The European Society of Cardiology specifies the type of therapy in diastolic HF based on: angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, non-dihydropyridine calcium channel blockers, diuretics. In order to improve the currently poor prognosis in this group of patients the treatment of diastolic HF must be optimised.

摘要

舒张性心力衰竭(HF)也被称为左心室收缩功能正常的 HF。收缩性和舒张性 HF 的区别是病理生理学上的,孤立的左心室功能障碍形式很少见。在舒张性 HF 中,左心室收缩功能正常或仅轻度受损,HF 的典型表现是由于左心室松弛和顺应性受损导致充盈压升高。舒张功能障碍的诱发因素包括老年、女性、肥胖、冠状动脉疾病、高血压和糖尿病。舒张性 HF 的治疗旨在阻止疾病进展、缓解症状、消除恶化并降低死亡率。治疗应包括降压治疗、维持窦性节律、预防心动过速、降低静脉压、预防心肌缺血和预防糖尿病。欧洲心脏病学会根据以下因素在舒张性 HF 中指定治疗类型:血管紧张素转换酶抑制剂、血管紧张素受体阻滞剂、β受体阻滞剂、非二氢吡啶类钙通道阻滞剂、利尿剂。为了改善这组患者目前较差的预后,必须优化舒张性 HF 的治疗。

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