Najjar Azadeh, Allami Abbas, Dodangeh Samira, Daei Mohammad Mahdi
Clinical Research Development Unit, Booalisina Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
Children Growth Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.
Ann Data Sci. 2022 Aug 4:1-12. doi: 10.1007/s40745-022-00425-5.
Electrocardiographic (ECG) changes have been investigated in the condition of coronavirus disease (COVID-19) indicating that COVID-19 infection exacerbates arrhythmias and triggers conduction abnormalities. However, the specific type of ECG abnormalities in COVID-19 and their impact on mortality fail to have been fully elucidated. The present retrospective, tertiary care hospital-based cross-sectional study was conducted by reviewing the medical records of all patients diagnosed with COVID-19 infection who were admitted to Booali Sina Hospital in Qazvin, Iran from March to July 2020. Demographic information, length of hospital stay, treatment outcome, and electrocardiographic information (heart rate, QTc interval, arrhythmias, and blocks) were extracted from the medical records of the patients. Finally, a total of 231 patients were enrolled in the study. Atrial fibrillation was a common arrhythmia, and the left anterior fascicular block was a common cardiac conduction defect other than sinus arrhythmia. The deceased patients were significantly older than the recovered ones (71 ± 14 vs. 57 ± 16 years, p < 0.001). Longer hospital stay (p = 0.036), non-sinus rhythm (p < 0.001), bundle and node blocks (p = 0.002), ST-T waves changes (p = 0.003), and Tachycardia (p = 0.024) were significantly prevalent in the deceased group. In baseline ECGs, no significant difference was observed in terms of the absolute size of QT; however, a prolonged QTc in the deceased was about twice of the recovered patients (using Bazett, Sagie, and Fridericia's formula). Serial ECGs are recommended to be taken from all hospitalized patients with COVID-19 due to increased in-hospital mortality in patients with prolonged QTc interval, non-sinus rhythms, ST-T changes, tachycardia, and bundle, and node blocks.
研究人员已对冠状病毒病（COVID-19）患者的心电图（ECG）变化进行了调查，结果表明COVID-19感染会加剧心律失常并引发传导异常。然而，COVID-19中ECG异常的具体类型及其对死亡率的影响尚未完全阐明。本项回顾性、基于三级护理医院的横断面研究，通过查阅2020年3月至7月在伊朗加兹温的布阿利·西纳医院收治的所有确诊为COVID-19感染患者的病历进行。从患者病历中提取人口统计学信息、住院时间、治疗结果和心电图信息（心率、QTc间期、心律失常和传导阻滞）。最终，共有231名患者纳入研究。心房颤动是常见的心律失常，左前分支阻滞是除窦性心律失常外常见的心脏传导缺陷。死亡患者明显比康复患者年龄大（71±14岁 vs. 57±16岁，p<0.001）。住院时间较长（p=0.036）、非窦性心律（p<0.001）、束支和结区阻滞（p=0.002）、ST-T波改变（p=0.003）和心动过速（p=0.024）在死亡组中显著更常见。在基线心电图中，QT的绝对大小未观察到显著差异；然而，死亡患者的QTc延长约为康复患者的两倍（使用巴泽特、萨吉和弗里德里西亚公式）。由于QTc间期延长、非窦性心律、ST-T改变、心动过速以及束支和结区阻滞的患者院内死亡率增加，建议对所有住院的COVID-19患者进行系列心电图检查。
