Gao Li-bo, Zhong Shu-rong, Jing Qiang
Department of Forensic Medicine, Kunming Medical College, Kunming, Yunnan, P.R. China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010 Dec;27(6):650-3. doi: 10.3760/cma.j.issn.1003-9406.2010.06.010.
The enzyme catechol-O-methyltransferase (COMT) transfers a methyl group from S-adenosylmethionine to the benzene ring of catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine. This methylation results in the degradation of catecholamines. The involvement of the COMT gene in the metabolic pathway of these neurotransmitters has made it an attractive candidate gene for many psychiatric disorders. This review focuses on the association between the genetic polymorphisms of COMT gene and psychiatric disorders.
儿茶酚-O-甲基转移酶（COMT）可将甲基从S-腺苷甲硫氨酸转移至儿茶酚胺的苯环上，这些儿茶酚胺包括神经递质多巴胺、肾上腺素和去甲肾上腺素。这种甲基化作用会导致儿茶酚胺降解。COMT基因参与这些神经递质的代谢途径，这使其成为许多精神疾病颇具吸引力的候选基因。本综述聚焦于COMT基因的遗传多态性与精神疾病之间的关联。
