Klockenbusch W, Distler W, von Ditfurth M, Graf M, Jahn K
Universitäts-Frauenklinik Düsseldorf.
Geburtshilfe Frauenheilkd. 1990 May;50(5):383-7. doi: 10.1055/s-2008-1026266.
The present study in 37 hyperprolactinaemic patients was performed, to investigate the relationship between radiographic changes of the pituitary region and serum prolactin levels, clinical signs and the results of dynamic tests. Prolactin responsiveness after metoclopramide- and TRH-injection and the nocturnal profile of serum prolactin were examined in 25 women. The results of the dynamic tests did not correlate with the radiological diagnosis. However, serum prolactin concentrations correlated strongly with the radiographic evidence of a pituitary tumour. The results show, that prolactin stimulation tests and the evaluation of the nocturnal secretory pattern of prolactin are not useful for differentiating between adenoma and nonadenoma caused hyperprolactinaemia. However, determinations of prolactin serum levels are of great clinical importance in the diagnosis of prolactinomas.
本研究对37例高催乳素血症患者进行，以探讨垂体区域的影像学改变与血清催乳素水平、临床体征及动态试验结果之间的关系。对25名女性进行了甲氧氯普胺和促甲状腺激素释放激素注射后的催乳素反应性以及血清催乳素的夜间变化情况检查。动态试验结果与放射学诊断不相关。然而，血清催乳素浓度与垂体肿瘤的影像学证据密切相关。结果表明，催乳素刺激试验及催乳素夜间分泌模式评估对于鉴别腺瘤性和非腺瘤性高催乳素血症并无帮助。然而，测定血清催乳素水平在催乳素瘤的诊断中具有重要的临床意义。
