Carol W, Lauterbach H, Klinger G, Unger A, Michels W
Klinik für Frauenheilkunde und Geburtshilfe Bereichs Medizin der Friedrich-Schiller-Universität Jena.
Zentralbl Gynakol. 1988;110(23):1515-21.
In 31 patients taking oral contraceptives (o.c.) for a period between 1 year to more than 3 years, basal serum prolactin levels and metoclopramide induced prolactin values were determined 30 and 60 minutes following an i.v. injection of 10 mg of metoclopramide. The basal prolactin levels were elevated in 7 women to more than 1,000 mU l. The 3 groups of patients taking o.c. with different estrogen doses showed higher drug induced increase of their prolactin levels than the controls. These differences were statistically significant between groups I and III and the control group. No differences could be found between the challenged values of the users groups. The prolactin increase challenged with 200 micrograms TRH in 5 women under o.c. was considerably smaller than that observed in the metoclopramide groups, but exceeded the TRH induced levels found in the controls. The significance of these findings is discussed with special reference to the promotion of prolactinomas.
对31名服用口服避孕药1年至3年以上的患者，在静脉注射10毫克胃复安后30分钟和60分钟，测定其基础血清催乳素水平以及胃复安诱导的催乳素值。7名女性的基础催乳素水平升高至超过1000 mU/l。服用不同雌激素剂量口服避孕药的3组患者，其药物诱导的催乳素水平升高幅度高于对照组。第一组和第三组与对照组之间的这些差异具有统计学意义。各使用组的激发值之间未发现差异。5名服用口服避孕药女性经200微克促甲状腺激素释放激素激发后的催乳素升高幅度，明显小于胃复安组观察到的幅度，但超过了对照组中促甲状腺激素释放激素诱导的水平。结合催乳素瘤的发展，对这些发现的意义进行了讨论。
