Main J, Thomas T, Wilkinson R
Renal Unit, Freeman Hospital, Newcastle upon Tyne, UK.
Nephrol Dial Transplant. 1990;5(5):369-75. doi: 10.1093/ndt/5.5.369.
Leukocyte cation content and sodium pump transport were measured in 14 undialysed uraemic and 15 CAPD patients and compared with results from healthy controls. Sodium content was elevated in the undialysed group compared with the CAPD group (P = 0.05) or the healthy controls (P less than 0.001), but this abnormality could not be clearly attributed to increased sodium influx or reduced sodium pumping. Sodium content correlated with plasma urea (rs = 0.69, P = 0.005) and creatinine (rs = 0.56, P = 0.031) concentrations in the CAPD group only. In subgroups of 12 undialysed and ten CAPD patients, erythrocyte sodium content and pump transport were measured at the same time as the leukocyte studies. Erythrocyte sodium was less in the undialysed group (P less than 0.01) and again there was no evidence of significant sodium-pump inhibition. The abnormalities in sodium content in undialysed patients were therefore in opposite directions in the two cell types, and were significantly less in both cell types in CAPD patients. These results emphasise the dangers of assuming that abnormalities of sodium transport seen in a single cell type can be taken as evidence of a generalised abnormality.
对14例未透析的尿毒症患者和15例持续性非卧床腹膜透析（CAPD）患者的白细胞阳离子含量和钠泵转运进行了测量，并与健康对照组的结果进行了比较。与CAPD组（P = 0.05）或健康对照组（P < 0.001）相比，未透析组的钠含量升高，但这种异常不能明确归因于钠流入增加或钠泵功能降低。仅在CAPD组中，钠含量与血浆尿素（rs = 0.69，P = 0.005）和肌酐（rs = 0.56，P = 0.031）浓度相关。在12例未透析患者和10例CAPD患者的亚组中，红细胞钠含量和泵转运与白细胞研究同时进行测量。未透析组的红细胞钠含量较低（P < 0.01），同样没有证据表明存在明显的钠泵抑制。因此，未透析患者钠含量的异常在两种细胞类型中方向相反，且在CAPD患者的两种细胞类型中均明显较轻。这些结果强调了假设在单一细胞类型中观察到的钠转运异常可作为全身性异常证据的危险性。
