Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.
J Chromatogr A. 2011 Jan 21;1218(3):408-15. doi: 10.1016/j.chroma.2010.11.048. Epub 2010 Nov 27.
A synthetic approach for synthesizing spherical aminopropyl-functionalized ethane-bridged periodic mesoporous organosilicas (APEPMOs) is reported. The mesoporous material was prepared by a one-step co-condensation of 1,2-bis(triethoxysilyl)ethane (BTSE) and 3-aminopropyltriethoxysilane (APTES) using cetyltrimethylammonium chlorine (C(18)TACl) as a template with the aid of a co-solvent (methanol) in basic medium. The APEPMOs were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), powder X-ray diffraction (XRD), nitrogen sorption measurement, Fourier transform infrared spectroscopy (FT-IR) and elemental analysis. It was shown that this material exhibited spherical morphology, ordered cubic mesostructure and good mechanical strength. The APEPMOs were tested as a potential stationary phase for liquid chromatography (LC) because the column exhibited reduced back pressure. Moreover, they exhibited good chemical stability in basic mobile phase, which can be ascribed to the ethane groups in the mesoporous framework.
一种合成球形氨基丙基功能化乙烷桥联周期性介孔有机硅（APEPMOs）的方法。介孔材料是通过在碱性介质中使用十六烷基三甲基氯化铵（C（18）TACl）作为模板，辅助共溶剂（甲醇），一步共缩合 1,2-双（三乙氧基硅基）乙烷（BTSE）和 3-氨丙基三乙氧基硅烷（APTES）制备的。APEPMOs 的结构通过透射电子显微镜（TEM）、扫描电子显微镜（SEM）、粉末 X 射线衍射（XRD）、氮气吸附测量、傅里叶变换红外光谱（FT-IR）和元素分析进行了表征。结果表明，该材料具有球形形貌、有序立方介孔结构和良好的机械强度。由于该柱的背压降低，APEPMOs 被测试为液相色谱（LC）的潜在固定相。此外，由于介孔骨架中的乙烷基团，它们在碱性流动相中表现出良好的化学稳定性。
