Guertin Jason R, Liu Aihua, Abrahamowicz Michal, Cohen David J, Ismail Salma, LeLorier Jacques, Brophy James M, Rinfret Stéphane
Centre Hospitalier de Université de Montréal Research Centre, Université de Montréal, Quebec, Canada.
Circ Cardiovasc Qual Outcomes. 2011 Jan 1;4(1):46-52. doi: 10.1161/CIRCOUTCOMES.109.915421. Epub 2010 Dec 14.
Percutaneous coronary intervention (PCI) remains limited by the risk of restenosis. Patients' perceptions of the health benefits and value of avoiding restenosis are incompletely known.
We used a contingent valuation approach to assess the willingness to pay (WTP) for a hypothetical treatment that eliminates the risk of restenosis among 270 PCI patients. Patients were provided with a scenario describing a baseline 10% or 20% probability of restenosis in the year following the procedure, which could lead to repeat PCI or, more rarely, bypass surgery, without any increase in mortality. Six different "take it or leave it" bids ($500, $1000, $1500, $2000, $2500, and $3000) and both risk levels were randomly assigned. Multiple logistic regression was used to identify independent predictors of a positive response to the WTP question. Using nonparametric methods, the median WTP to eliminate the risk of restenosis was estimated at $2802. As expected, higher income was independently associated with a higher probability of a positive response to the WTP question (odds ratio, 2.81; 95% CI, 1.32 to 5.97). Bids also were independently associated with the probability of being willing to pay, and this association followed a quadratic effect. Below $1500, bid had little impact on patient answers. However, as prices increased, the probability of being willing to pay started to decrease sharply.
The potential to eliminate the risk of restenosis, a benign complication, would have substantial value for patients undergoing PCI.
经皮冠状动脉介入治疗(PCI)仍受再狭窄风险的限制。患者对避免再狭窄的健康益处和价值的认知尚不完全清楚。
我们采用条件估值法评估了270例PCI患者为一种可消除再狭窄风险的假设性治疗愿意支付的费用(WTP)。向患者提供了一个情景描述,即术后一年再狭窄的基线概率为10%或20%,这可能导致再次PCI,或更罕见的情况下导致搭桥手术,且死亡率无增加。六个不同的“接受或放弃”报价(500美元、1000美元、1500美元、2000美元、2500美元和3000美元)以及两种风险水平均被随机分配。使用多元逻辑回归来确定对WTP问题做出积极回应的独立预测因素。采用非参数方法,消除再狭窄风险的WTP中位数估计为2802美元。正如预期的那样,较高的收入与对WTP问题做出积极回应较高的概率独立相关(优势比,2.81;95%可信区间,1.32至5.97)。报价也与愿意支付的概率独立相关,且这种关联呈现二次效应。低于1500美元时,报价对患者的回答影响不大。然而,随着价格上涨,愿意支付的概率开始急剧下降。
消除再狭窄风险(一种良性并发症)的可能性对接受PCI的患者具有重大价值。