可待因治疗儿童急性咳嗽。
Codeine for acute cough in children.
机构信息
BC Children's Hospital, Department of Pediatrics, Room K4-226, Ambulatory Care Bldg, 4480 Oak St, Vancouver, BC V6H 3V4.
出版信息
Can Fam Physician. 2010 Dec;56(12):1293-4.
Abstract
QUESTION
Owing to Health Canada's recent recommendations to avoid the use of over-the-counter cough and cold medications in preschool children, I was looking at other antitussive medications for acute cough. Codeine was recommended in the past for this indication. What is the evidence for its use and how effective and safe is it?
ANSWER
Cough is one of the most common symptoms in children, and the opioid codeine has known antitussive qualities mediated by a central nervous system pathway. However, current evidence finds codeine to be no more effective than placebo for acute cough in children. Its safety profile and recent advances in understanding codeine's variable effectiveness prohibit recommending codeine for cough in children.
摘要
问题
由于加拿大卫生部最近建议学龄前儿童避免使用非处方止咳药和感冒药，我正在寻找其他镇咳药来治疗急性咳嗽。过去曾推荐可待因用于该适应症。它的使用证据是什么？它的疗效和安全性如何？
答案
咳嗽是儿童最常见的症状之一，阿片类药物可待因具有通过中枢神经系统途径发挥的已知镇咳作用。然而，目前的证据表明，可待因治疗儿童急性咳嗽的效果并不优于安慰剂。其安全性概况和对可待因疗效差异的最新认识，使得不能推荐可待因用于儿童咳嗽。
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