Maeda Megumi, Miura Yoshie, Nishimura Yasumitsu, Murakami Shuko, Hayashi Hiroaki, Kumagai Naoko, Hatayama Tamayo, Katoh Minako, Miyahara Naomi, Yamamoto Shoko, Fukuoka Kazuya, Kishimoto Takumi, Nakano Takashi, Otsuki Takemi
Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki 7010192, Japan.
Clin Med Circ Respirat Pulm Med. 2008 Mar 26;2:11-7. doi: 10.4137/ccrpm.s577.
It is common knowledge that asbestos exposure causes asbestos-related diseases such as asbestosis, lung cancer and malignant mesothelioma (MM) not only in people who have handled asbestos in the work environment, but also in residents living near factories that handle asbestos. These facts have been an enormous medical and social problem in Japan since the summer of 2005. We focused on the immunological effects of asbestos and silica on the human immune system. In this brief review, we present immunological changes in patients with MM and outline their experimental detection. For example, there is over-expression of bcl-2 in CD4+ peripheral T-cells, high plasma concentrations of interleukin (IL)-10 and transforming growth factor (TGF)-ß, and multiple over-representation of T cell receptor (TcR)-Vß in peripheral CD3+ T-cells found in MM patients. We also detail an experimental long-term exposure T-cell model. Analysis of the immunological effects of asbestos may help our understanding of the biological effects of asbestos.
众所周知，接触石棉不仅会使在工作环境中接触过石棉的人患上石棉沉着病、肺癌和恶性间皮瘤（MM）等与石棉相关的疾病，还会使居住在石棉处理工厂附近的居民患病。自2005年夏天以来，这些事实在日本一直是巨大的医学和社会问题。我们聚焦于石棉和二氧化硅对人体免疫系统的免疫作用。在这篇简短的综述中，我们阐述了MM患者的免疫变化，并概述了其实验检测方法。例如，MM患者外周血CD4+ T细胞中bcl-2过表达，血浆中白细胞介素（IL）-10和转化生长因子（TGF）-β浓度升高，外周血CD3+ T细胞中T细胞受体（TcR）-Vβ多克隆过度表达。我们还详细介绍了一个实验性长期暴露T细胞模型。对石棉免疫作用的分析可能有助于我们理解石棉的生物学效应。
