Bulmer J N, Morrison L, Johnson P M, Meager A
Department of Pathology, University of Leeds, UK.
Am J Reprod Immunol. 1990 Mar-Apr;22(3-4):109-16. doi: 10.1111/j.1600-0897.1990.tb00652.x.
Interferon (IFN)alpha, beta, and gamma have been localized in normal and pathological human pregnancy using both polyclonal and monoclonal antibodies in immunohistochemical techniques. IFN alpha was localized to fetal chorionic villous syncytiotrophoblast throughout normal pregnancy, as well as to extravillous trophoblast in the placental bed and chorion lave. Maternal decidual leukocytes, as well as fetal Hofbauer cells in the villous mesenchyme, also contained IFN alpha, IFN gamma was detected in villous syncytiotrophoblast, while anti-IFN beta showed only patchy weak reactivity with syncytiotrophoblast. Reaction patterns on ectopic pregnancy tissues were similar to those in early intrauterine pregnancy. In molar pregnancy, reactivity for IFN alpha, beta, and gamma was observed in syncytiotrophoblast. Along with their potential anti-viral effects, placental interferons could play a role in local immunomodulation or in regulation of embryonic cell proliferation and differentiation.
利用免疫组织化学技术中的多克隆抗体和单克隆抗体，已在正常和病理状态的人类妊娠组织中定位了α、β和γ干扰素（IFN）。在整个正常妊娠期间，IFNα定位于胎儿绒毛膜绒毛合体滋养层，以及胎盘床和胎膜中的绒毛外滋养层。母体蜕膜白细胞以及绒毛间质中的胎儿霍夫鲍尔细胞也含有IFNα。在绒毛合体滋养层中检测到了IFNγ，而抗IFNβ仅显示与合体滋养层有散在的微弱反应。异位妊娠组织的反应模式与早期宫内妊娠相似。在葡萄胎妊娠中，在合体滋养层中观察到了对IFNα、β和γ的反应性。除了其潜在的抗病毒作用外，胎盘干扰素可能在局部免疫调节或胚胎细胞增殖与分化的调节中发挥作用。
