Division of Gastroenterology, Department of Medicine, New York University School of Medicine, New York, New York.
J Hosp Med. 2010 Jul-Aug;5 Suppl 3:S8-17. doi: 10.1002/jhm.784.
The development of hyponatremia represents an ominous event in the progression of cirrhosis to end-stage liver disease. It usually develops in those with refractory ascites and is a manifestation of the non-osmotic release of arginine vasopressin (AVP). In the hospitalized cirrhotic patient, hyponatremia is associated with increased disease severity and mortality. In this article, we review the pathophysiology of hyponatremia, its clinical implications, evaluation, and treatment.
低钠血症的发展是肝硬化进展为终末期肝病的一个严重事件。它通常发生在难治性腹水的患者中，是精氨酸加压素（AVP）非渗透性释放的表现。在住院的肝硬化患者中，低钠血症与疾病严重程度和死亡率增加有关。本文综述了低钠血症的病理生理学、临床意义、评估和治疗。
