Milhaud G, Calmettes C, Jullienne A, Boccard B, Desplan C, Moukhtar M S
Sem Hop. 1978 May;54(13-16):489-95.
Hypercalcaemia always results in serious clinical sequalae and, if not treated, carries a most unfavourable prognosis. The clinician will gain major diagnostic help from an evaluation of the calcitonin and parathyroid hormone blood levels. With regard to parathyroid hormone we have developed, for the first time, a radioimmunoassay which is specific for the estimation of biologically active hormone in the circulation. We are dealing here with an unusual radioimmunological situation as the immunochemical sites are generally quite distinct from those associated with hormonal activity. We are presenting in this first paper the normal values and also the variations that occur in different types of hypercalcaemia. The comparison of these results with those obtained by the usual methods of estimation for parathyroid hormone assay lacking in biological activity shows the value of this new technique.
高钙血症总会导致严重的临床后果，若不治疗，预后极差。临床医生通过评估降钙素和甲状旁腺激素的血液水平可获得重要的诊断帮助。关于甲状旁腺激素，我们首次开发了一种放射免疫测定法，用于特异性测定循环中具有生物活性的激素。我们在此面临一种不同寻常的放射免疫情况，因为免疫化学位点通常与激素活性位点截然不同。在这第一篇论文中，我们给出了正常数值以及不同类型高钙血症中出现的变化情况。将这些结果与通过缺乏生物活性的甲状旁腺激素常规测定方法所获得的结果进行比较，显示出这项新技术的价值。
