Bravidor C, Wetzel K, John K
Universitäts-Kinderklinik und Poliklinik, Jussuf Ibrahim.
Kinderarztl Prax. 1990 May;58(5):261-6.
In a retrospective study the data of 43 children suffering from epilepsy were analysed. The first epileptic seizure was observed in all patients before the age of 6 years. The relationship between behavioral disturbances with hyperactivity, developmental respectively intellectual test scores, and efficiency of antileptic drug therapy have been investigated. Psychological testings were performed two times, at first after the start of drug therapy, and a second time after a period of 1 year 11 months in average. There were behavioral disturbances with hyperactivity in 20 patients. The epileptic seizures were intractable in 26 patients. The developmental respectively intellectual test scores have decreased to values below 85 in 7 patients with and 3 patients without hyperactivity. There was a decline by more than 10 points of the IQ score between first and second psychological testings in 16 patients with and 4 patients without hyperactivity, respectively in 17 patients with intractable seizures, but in one child only with prompt cessation of epileptic seizures. An increasing retardation of mental development was seen in children with hyperactivity at the start of seizures, in children with intractable seizures, but especially in patients with a combination of intractable seizures and hyperactivity.
在一项回顾性研究中,对43例癫痫患儿的数据进行了分析。所有患者首次癫痫发作均在6岁之前被观察到。研究了多动行为障碍、发育及智力测试分数与抗癫痫药物治疗效果之间的关系。心理测试进行了两次,第一次在药物治疗开始后,第二次平均在1年11个月后。20例患者存在多动行为障碍。26例患者的癫痫发作难以控制。7例有多动症和3例无多动症的患者,其发育及智力测试分数降至85分以下。16例有多动症和4例无多动症的患者,分别有17例癫痫发作难以控制的患者,在第一次和第二次心理测试之间智商分数下降超过10分,但只有1名儿童癫痫发作迅速停止。癫痫发作开始时有多动症的儿童、癫痫发作难以控制的儿童,尤其是癫痫发作难以控制且伴有多动症的患者,智力发育迟缓情况日益加重。