Department of Radiological Sciences, University of Messina, Messina, Italy.
Phys Med Biol. 2011 Jan 21;56(2):357-65. doi: 10.1088/0031-9155/56/2/005. Epub 2010 Dec 15.
We applied a Monte Carlo simulation in Geant4 in order to calculate the absorbed fractions for monoenergetic electrons in the energy interval between 10 keV and 2 MeV, uniformly distributed in ellipsoids made from soft tissue. For each volume, we simulated a spherical shape, four oblate and four prolate ellipsoids, and one scalene shape. For each energy and for every geometrical configuration, an analytical relationship between the absorbed fraction and a 'generalized radius' was found, and the dependence of the fit parameters from electron energy is discussed and fitted by proper parametric functions. With the proposed formulation, the absorbed fraction for electrons in the 10-2000 keV energy range can be calculated for all volumes and for every ellipsoidal shape of practical interest. This method can be directly applied to evaluation of the absorbed fraction from the radionuclide emission of monoenergetic electrons, such as Auger or conversion electrons. The average deposited energy per disintegration in the case of extended beta spectra can be evaluated through integration. Two examples of application to a pure beta emitter such as (90)Y and to (131)I, whose emission include monoenergetic and beta electrons plus gamma photons, are presented. This approach represent a generalization of our previous studies, allowing a comprehensive treatment of absorbed fractions from electron and photon sources uniformly distributed in ellipsoidal volumes of any ellipticity and volume, in the whole range of practical interest for internal dosimetry in nuclear medicine applications, as well as in radiological protection estimations of doses from an internal contamination.
我们在 Geant4 中应用了蒙特卡罗模拟,以便计算能量在 10keV 到 2MeV 之间、均匀分布在软组织椭球体中的单能电子的吸收分数。对于每个体积,我们模拟了一个球体、四个扁球体和四个长球体以及一个不等边球体。对于每个能量和每个几何构型,我们发现吸收分数与“广义半径”之间存在分析关系,并讨论了拟合参数与电子能量的依赖性,并通过适当的参数函数进行拟合。通过提出的公式,可以计算出在 10keV 到 2000keV 能量范围内电子在所有体积和所有实际感兴趣的椭球形状中的吸收分数。该方法可直接应用于单能电子放射性核素发射的吸收分数的评估,例如俄歇电子或转换电子。对于扩展β谱,可以通过积分评估每一次衰变的平均沉积能量。我们通过两个应用示例展示了这种方法,一个是纯β发射体(90)Y,另一个是(131)I,其发射包括单能电子和β电子以及γ光子。这种方法是我们之前研究的推广,可以全面处理在核医学应用内部剂量学以及内部污染剂量的放射防护估算中,在整个实际感兴趣范围内,均匀分布在任何椭圆度和体积的椭球体中的电子和光子源的吸收分数。