Gonzalez-Baron M, Vicente J, Tomas M, Martin G, Martorell V, Garcia-Giron C, Garrido P, Gavilan J, Zamora P
Department of Medicine, Hospital La Paz, Facultad de Medicina, Universidad Autonoma, Madrid, Spain.
Am J Clin Oncol. 1990 Aug;13(4):312-4. doi: 10.1097/00000421-199008000-00009.
Cisplatin and 5-fluorouracil infusion combination produces a high response rate in squamous-cell carcinoma of the head and neck. Tegafur (Ftorafur) is an analog of 5-fluorouracil, and its oral form is well absorbed. This agent has a moderate toxicity. We report a study to determine the efficacy of the cisplatin (100 mg/m2, day 1) and tegafur (1,000 mg/m2 daily for 21 days) combination. Thirty-nine patients entered the study; 36 were evaluable for response. Overall response was 94%, with a 22% complete response. Toxicity was moderate. We conclude that the cisplatin and tegafur combination is active in untreated patients with head and neck cancer.
顺铂与5-氟尿嘧啶联合输注对头颈部鳞状细胞癌有较高的缓解率。替加氟（喃氟啶）是5-氟尿嘧啶的类似物，其口服剂型吸收良好。该药物毒性中等。我们报告一项研究，以确定顺铂（100mg/m²，第1天）与替加氟（1000mg/m²，每日一次，共21天）联合使用的疗效。39例患者进入该研究；36例可评估缓解情况。总体缓解率为94%，完全缓解率为22%。毒性为中等。我们得出结论，顺铂与替加氟联合方案对未经治疗的头颈癌患者有效。
