Enomoto Hirayuki, Nakamura Hideji, Komatsu-Kanatani Naoko, Liu Yu, Yoshida Kenya, Okuda Yorihide, Yamamoto Teruhisa, Liu Weidong, Nishiguchi Shuhei
Hirayuki Enomoto, Hideji Nakamura, Teruhisa Yamamoto, Weidong Liu, Shuhei Nishiguchi, Division of Hepatobiliary and Pancreatic Medicine, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, Japan.
World J Hepatol. 2009 Oct 31;1(1):98-102. doi: 10.4254/wjh.v1.i1.98.
To investigate the role of hepatoma-derived growth factor (HDGF) in liver development, especially in the hepatocyte differentiation.
We generated transgenic mice which overexpressed HDGF in hepatocytes under the transcriptional control of mouse albumin promoter/enhancer. To examine the effects of HDGF overexpression on hepatocyte differentiation, we investigated the expression patterns of the differentiation marker genes.
The HDGF transgenic mice developed normally and showed no apparent abnormality in the liver. However, the gene expression patterns of the liver in adult transgenic mice were similar to those of the neonatal liver in control mice.
These findings suggest that HDGF-overexpression partially suppresses hepatocyte maturation.
研究肝癌衍生生长因子（HDGF）在肝脏发育中的作用，尤其是在肝细胞分化中的作用。
我们构建了在小鼠白蛋白启动子/增强子转录控制下在肝细胞中过表达HDGF的转基因小鼠。为了检测HDGF过表达对肝细胞分化的影响，我们研究了分化标记基因的表达模式。
HDGF转基因小鼠发育正常，肝脏未出现明显异常。然而，成年转基因小鼠肝脏的基因表达模式与对照小鼠新生肝脏的相似。
这些发现表明HDGF过表达部分抑制了肝细胞成熟。
