Kazanski V E, Kamkin A G, Makarenko E Yu, Lysenko N N, Sutiagin P V, Bo Tian, Kiseleva I S
Department of Fundamental and Applied Physiology, Medico-Biological Faculty, N. I. Pirogov Russian State Medical University, Moscow, Russia.
Bull Exp Biol Med. 2010 Dec;150(1):1-5. doi: 10.1007/s10517-010-1052-7.
Whole-cell ionic currents through mechanically gated channels (MGC) were recorded in isolated cardiomyocytes under voltage clamp conditions. In unstrained cells, NO donors SNAP and DEA-NO activated MGC and induced MG-like currents. In contrast, in stretched cells with activated MGC, these NO-donors inactivated and inhibited MGC.
在电压钳制条件下，对分离的心肌细胞中通过机械门控通道（MGC）的全细胞离子电流进行了记录。在未受拉伸的细胞中，一氧化氮供体硝普钠（SNAP）和二乙胺NONOate（DEA-NO）激活MGC并诱导出类机械门控电流。相反，在MGC激活的拉伸细胞中，这些一氧化氮供体使MGC失活并产生抑制作用。
