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前额叶介导的抑制加工与白质微观结构：年龄和酗酒的影响。

Frontally mediated inhibitory processing and white matter microstructure: age and alcoholism effects.

机构信息

SRI International, 333 Ravenswood Ave, Menlo Park, CA 94025, USA.

出版信息

Psychopharmacology (Berl). 2011 Feb;213(4):669-79. doi: 10.1007/s00213-010-2073-7. Epub 2010 Dec 16.

DOI:10.1007/s00213-010-2073-7
PMID:21161189
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3033525/
Abstract

RATIONALE

The NOGO P3 event-related potential is a sensitive marker of alcoholism, relates to EEG oscillation in the δ and θ frequency ranges, and reflects activation of an inhibitory processing network. Degradation of white matter tracts related to age or alcoholism should negatively affect the oscillatory activity within the network.

OBJECTIVE

This study aims to evaluate the effect of alcoholism and age on δ and θ oscillations and the relationship between these oscillations and measures of white matter microstructural integrity.

METHODS

Data from ten long-term alcoholics to 25 nonalcoholic controls were used to derive P3 from Fz, Cz, and Pz using a visual GO/NOGO protocol. Total power and across trial phase synchrony measures were calculated for δ and θ frequencies. DTI, 1.5 T, data formed the basis of quantitative fiber tracking in the left and right cingulate bundles and the genu and splenium of the corpus callosum. Fractional anisotropy and diffusivity (λL and λT) measures were calculated from each tract.

RESULTS

NOGO P3 amplitude and δ power at Cz were smaller in alcoholics than controls. Lower δ total power was related to higher λT in the left and right cingulate bundles. GO P3 amplitude was lower and GO P3 latency was longer with advancing age, but none of the time-frequency analysis measures displayed significant age or diagnosis effects.

CONCLUSIONS

The relation of δ total power at CZ with λT in the cingulate bundles provides correlational evidence for a functional role of fronto-parietal white matter tracts in inhibitory processing.

摘要

原理

NOGO P3 事件相关电位是酒精中毒的敏感标志物，与 δ 和 θ 频率范围内的 EEG 振荡有关，反映了抑制处理网络的激活。与年龄或酒精中毒相关的白质束的退化应该会对网络内的振荡活动产生负面影响。

目的

本研究旨在评估酒精中毒和年龄对 δ 和 θ 振荡的影响，以及这些振荡与白质微观结构完整性测量之间的关系。

方法

使用视觉 GO/NOGO 协议，从 10 名长期酗酒者和 25 名非酗酒者对照者的数据中，从 Fz、Cz 和 Pz 导出 P3。计算 δ 和 θ 频率的总功率和跨试验相位同步测量值。DTI，1.5 T，数据为左、右扣带回束和胼胝体膝部和干部的定量纤维跟踪提供了基础。从每个束中计算了分数各向异性和扩散（λL 和 λT）测量值。

结果

与对照组相比，酗酒者的 NOGO P3 振幅和 Cz 处的 δ 功率较小。较低的 δ 总功率与左、右扣带回束中的 λT 较高有关。GO P3 振幅较低，GO P3 潜伏期较长，但这些时频分析测量值均与年龄或诊断无显著相关性。

结论

Cz 处 δ 总功率与扣带回束中的 λT 的关系为额顶叶白质束在抑制处理中的功能作用提供了相关证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc5f/3033525/9cfc0c928096/213_2010_2073_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc5f/3033525/d678ddd88e64/213_2010_2073_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc5f/3033525/7193be2088f1/213_2010_2073_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc5f/3033525/9cfc0c928096/213_2010_2073_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc5f/3033525/d678ddd88e64/213_2010_2073_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc5f/3033525/7193be2088f1/213_2010_2073_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc5f/3033525/9cfc0c928096/213_2010_2073_Fig3_HTML.jpg

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