Department of Intensive Care Unite, The Third Affiliated Hospital to Nantong University, Wuxi 214041, Jiangsu, China.
Breast Cancer Res Treat. 2011 Jun;127(3):813-8. doi: 10.1007/s10549-010-1294-0. Epub 2010 Dec 15.
The matrix metalloproteinases (MMP) can degrade various components of the extracellular matrix and its functional genetic polymorphisms may be associated with breast cancer risk. However, this relationship remains controversial. A meta-analysis was conducted in order to investigate the potential association between four polymorphisms in the MMP gene and breast cancer risk. A database search yielded a total of 9 studies involving 2,597 cases and 2,618 controls. Four polymorphisms were included in the meta-analysis: MMP-1 -1607 2G/1G (rs1799750), MMP-2 -1306 C/T (rs243865), MMP-3 -1171 6A/5A (rs3025058) and MMP-9 -1562 C/T (rs3918242). Crude odds ratios (OR) with 95% confidence intervals (CI) were used to assess the strength of association. When all the studies were pooled into the meta-analysis, we found that breast cancer cases had a significantly higher frequency of CC genotype (OR = 1.27, 95% CI = 1.10, 1.47; P = 0.001) and lower frequency of CT genotype (OR = 0.78, 95% CI = 0.67, 0.91; P = 0.001) of MMP-2. No significant difference was found in any genotype of MMP-1, MMP-3 or MMP-9. In conclusion, this meta-analysis suggested that MMP-2 -1306 C/T polymorphism may contribute to breast cancer susceptibility. More studies were needed especially in Asians in the future.
基质金属蛋白酶（MMP）可以降解细胞外基质的各种成分，其功能遗传多态性可能与乳腺癌风险相关。然而，这种关系仍然存在争议。进行了一项荟萃分析，以研究 MMP 基因中的四个遗传多态性与乳腺癌风险之间的潜在关联。数据库搜索共产生了 9 项研究，涉及 2597 例病例和 2618 例对照。有 4 个多态性被纳入荟萃分析：MMP-1-1607 2G/1G(rs1799750)、MMP-2-1306 C/T(rs243865)、MMP-3-1171 6A/5A(rs3025058)和 MMP-9-1562 C/T(rs3918242)。使用粗 Odds 比（OR）和 95%置信区间（CI）来评估关联的强度。当所有研究都被纳入荟萃分析时，我们发现乳腺癌病例的 CC 基因型频率明显较高（OR=1.27，95%CI=1.10，1.47；P=0.001），CT 基因型频率较低（OR=0.78，95%CI=0.67，0.91；P=0.001）。MMP-1、MMP-3 或 MMP-9 的任何基因型均未发现显著差异。综上所述，这项荟萃分析表明 MMP-2-1306 C/T 多态性可能与乳腺癌易感性有关。未来还需要更多的研究，特别是在亚洲人群中。
