Department of Neurology, Jagiellonian University Medical College, 3 Botaniczna street, 31-503, Kraków, Poland.
J Neural Transm (Vienna). 2011 Feb;118(2):241-7. doi: 10.1007/s00702-010-0533-1. Epub 2010 Dec 16.
Tremor often accompanies dystonia and some other movement disorders. There are no reports describing tremor in patients with hemifacial spasm (HFS). The aim of the study was to assess the occurrence, type and parameters of tremor in HFS patients. The study included 47 HFS patients (mean age: 58.6 ± 10.7-years-old) and 48 healthy volunteers matched by sex and age. Tremor was assessed clinically and objectively using a triaxial accelerometer and EMG. A load test with 500 g weight was performed in order to identify physiological tremor. The Clinical Global Impression-Severity scale (CGI-S) was used to assess the severity of HFS. Neurological examination revealed tremor in 19 patients and 5 control subjects, and the objective methods postural and kinetic hand tremor was confirmed. Among the patients we identified: one case of psychogenic tremor, two patients were diagnosed with essential tremor, six patients had essential tremor in one hand and enhanced physiologic tremor in the other, seven patients had essential tremor in both hands and three patients had physiological tremor in both hands. Five control subjects revealed enhanced the physiological tremor type. The occurrence of hand tremor was associated with higher severity of HFS, as assessed by CGI score. Tremor accompanies HFS in 40% of cases and 10% of control subjects. The aetiology of hand tremor in patients with HFS is unknown. However, it may be associated with compression of the tremor oscillator located in the medulla.
震颤常伴有肌张力障碍和其他一些运动障碍。目前尚无描述面肌痉挛（HFS）患者震颤的报道。本研究旨在评估 HFS 患者震颤的发生、类型和参数。该研究纳入了 47 例 HFS 患者（平均年龄：58.6 ± 10.7 岁）和 48 名性别和年龄匹配的健康志愿者。使用三轴加速度计和肌电图对震颤进行临床和客观评估。进行了 500 克重物负荷试验以识别生理性震颤。使用临床总体印象严重程度量表（CGI-S）评估 HFS 的严重程度。神经系统检查发现 19 例患者和 5 例对照存在震颤，客观方法证实存在姿势性和动力性手部震颤。在患者中我们确定了：1 例心因性震颤，2 例特发性震颤，6 例单手特发性震颤伴对侧生理性震颤增强，7 例双手特发性震颤，3 例双手生理性震颤。5 例对照显示生理性震颤增强。手部震颤的发生与 CGI 评分评估的 HFS 严重程度相关。HFS 患者中手部震颤的发生率为 40%，对照组为 10%。HFS 患者手部震颤的病因尚不清楚。然而，它可能与位于延髓的震颤振荡器受压有关。
