Department of Psychology, University of Helsinki, FIN-00014 Helsinki, Finland.
Psychol Health. 2011 Jan;26(1):61-75. doi: 10.1080/08870440903270690.
We examined the association between adulthood emotionality-activity-sociability temperament scale and preclinical atherosclerosis and, whether this association is mediated by cardiovascular risk factors (low-density lipoprotein cholesterol, systolic blood pressure, diastolic blood pressure and body-mass index (BMI)). The participants were a nationally representative sample of 537 men and 811 women from the Cardiovascular Risk in Young Finns study aged 15-30 years at the baseline in 1992 and aged 24-39 years at the follow-up in 2001. Carotid atherosclerosis was assessed by ultrasound scans of the common carotid artery intima-media thickness (IMT) and brachial flow-mediated dilation (FMD). In men, there was an association between the temperament dimension activity and IMT (β = 0.08, p = 0.036) which was partially mediated by BMI (β decreased from 0.08 to 0.05; p-value of Sobel test = 0.002). However, after correction for multiple comparisons the association between IMT and the temperament dimension activity in men was only of borderline significance. In women, there were no associations between temperament and IMT or FMD. These results suggest that a highly active temperament may contribute to early signs of atherosclerosis in men and that body mass may mediate this association.
我们研究了成人情绪性-活动性-社交性气质量表与临床前动脉粥样硬化之间的关系，以及这种关系是否受心血管风险因素（低密度脂蛋白胆固醇、收缩压、舒张压和体重指数（BMI））的影响。参与者是来自心血管风险在年轻芬兰人中的一个全国代表性样本，包括 537 名男性和 811 名女性，他们在 1992 年基线时年龄为 15-30 岁，在 2001 年随访时年龄为 24-39 岁。颈动脉粥样硬化通过颈总动脉内膜-中层厚度（IMT）和肱动脉血流介导的扩张（FMD）的超声扫描来评估。在男性中，气质维度活动与 IMT 之间存在关联（β=0.08，p=0.036），这部分由 BMI 介导（β从 0.08 下降到 0.05；Sobel 检验的 p 值=0.002）。然而，在进行多次比较校正后，男性 IMT 与气质维度活动之间的关联仅具有边缘显著性。在女性中，气质与 IMT 或 FMD 之间没有关联。这些结果表明，高度活跃的气质可能导致男性早期动脉粥样硬化的迹象，而体重可能介导这种关联。
