非-α-生育酚，一种新型维生素 E 类似物的不对称合成及生物活性。

Asymmetric synthesis and biological activity of nor-α-tocopherol, a new vitamin E analogue.

机构信息

Department of Chemistry, University of Basel, St. Johanns Ring 19, 4056 Basel, Switzerland.

出版信息

Chembiochem. 2011 Jan 3;12(1):118-24. doi: 10.1002/cbic.201000511.

DOI:10.1002/cbic.201000511

PMID:21161968

Abstract

The vitamin E analogues (2R,4'R,8'R)-nor-α-tocopherol (94 % de) and (2RS,4'R,8'R)-nor-α-tocopherol have been synthesized from (all R)-hexahydrofarnesol and phytol, respectively. According to in vitro experiments with murine macrophages nor-α-tocopherol is an anti-inflammatory compound more potent than α-tocopherol.

摘要

维生素 E 类似物（2R,4'R,8'R）-去甲-α-生育酚（94％de）和（2RS,4'R,8'R）-去甲-α-生育酚分别由（全 R）-六氢法呢醇和植醇合成。根据与鼠巨噬细胞的体外实验，去甲-α-生育酚是一种比 α-生育酚更有效的抗炎化合物。