[胃缺血/再灌注损伤诱导大鼠室旁核和孤束核内C-fos的表达]
[C-fos expression within PVN and NTS of the rat induced by gastric ischemia/reperfusion injury].
作者信息
Zhang Yong-Mei, Zhang Jian-Fu, Chen You-Ting, Yan Chang-Dong, Zhou Xiu-Ping
机构信息
Department of Physiology, Xuzhou Medical College, Xuzhou 221002, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2004 Feb;20(1):20-3.
AIM
To investigate the effect of paraventricular nucleus (PVN) stimulation and the c-fos expression within PVN and nucleus tractus solitarius (NTS) of the rat following gastric ischemia/reperfusion injury (GI/RI).
METHODS
The rat celiac artery was clamped for thirty minutes and reperfused for sixty minutes, using Fos immunohistochemical method (ABC method) examined the c-fos expression within PVN and NTS.
RESULTS
(1) Both electrical and chemical stimulation of the PVN obviously attenuated the GI/ RI. (2) Bilateral electrolytic lesion of NTS could eliminate the protective effect of electrical stimulation of the PVN. (3) The Fos-like immunoreactive neurons were increased in bilateral PVN and NTS by GI/RI.
CONCLUSION
The function of PVN and NTS could be affected by the GI/RI noxious stimulation. PVN, NTS were involved in the regulation of GI/RI.
目的
探讨胃缺血/再灌注损伤（GI/RI）后，室旁核（PVN）刺激及大鼠PVN和孤束核（NTS）内c-fos表达的影响。
方法
夹闭大鼠腹腔动脉30分钟，再灌注60分钟，采用Fos免疫组化方法（ABC法）检测PVN和NTS内的c-fos表达。
结果
（1）PVN的电刺激和化学刺激均明显减轻GI/RI。（2）NTS的双侧电解损伤可消除PVN电刺激的保护作用。（3）GI/RI使双侧PVN和NTS中Fos样免疫反应性神经元增加。
结论
GI/RI有害刺激可影响PVN和NTS的功能。PVN、NTS参与GI/RI的调节。
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