麻风分枝杆菌：基因、假基因和遗传多样性。
Mycobacterium leprae: genes, pseudogenes and genetic diversity.
机构信息
Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Station 19, CH-1015 Lausanne, Switzerland.
出版信息
Future Microbiol. 2011 Jan;6(1):57-71. doi: 10.2217/fmb.10.153.
Abstract
Leprosy, which has afflicted human populations for millenia, results from infection with Mycobacterium leprae, an unculturable pathogen with an exceptionally long generation time. Considerable insight into the biology and drug resistance of the leprosy bacillus has been obtained from genomics. M. leprae has undergone reductive evolution and pseudogenes now occupy half of its genome. Comparative genomics of four different strains revealed remarkable conservation of the genome (99.995% identity) yet uncovered 215 polymorphic sites, mainly single nucleotide polymorphisms, and a handful of new pseudogenes. Mapping these polymorphisms in a large panel of strains defined 16 single nucleotide polymorphism-subtypes that showed strong geographical associations and helped retrace the evolution of M. leprae.
摘要
麻风病是一种影响人类数千年的疾病，它是由麻风分枝杆菌（Mycobacterium leprae）感染引起的，麻风分枝杆菌是一种无法培养的病原体，其世代时间非常长。基因组学为我们深入了解麻风杆菌的生物学和耐药性提供了大量信息。麻风分枝杆菌经历了还原进化，现在假基因占据了其基因组的一半。对四种不同菌株的比较基因组学研究表明，基因组具有惊人的保守性（99.995%的同一性），但发现了 215 个多态性位点，主要是单核苷酸多态性，还有少数新的假基因。在一个大型菌株面板中对这些多态性进行映射，确定了 16 种单核苷酸多态性亚型，这些亚型表现出强烈的地理相关性，并有助于追溯麻风分枝杆菌的进化。
相似文献
1
Mycobacterium leprae: genes, pseudogenes and genetic diversity.麻风分枝杆菌：基因、假基因和遗传多样性。
Future Microbiol. 2011 Jan;6(1):57-71. doi: 10.2217/fmb.10.153.
2
Comparative genomic and phylogeographic analysis of Mycobacterium leprae.麻风分枝杆菌的比较基因组学和系统地理学分析。
Nat Genet. 2009 Dec;41(12):1282-9. doi: 10.1038/ng.477. Epub 2009 Nov 1.
3
On the origin of leprosy.论麻风病的起源。
Science. 2005 May 13;308(5724):1040-2. doi: 10.1126/science/1109759.
4
Identification of novel open reading frames in the intergenic regions of Mycobacterium leprae genome and detection of transcript by qRT-PCR.鉴定麻风分枝杆菌基因组基因间区的新开放阅读框并通过 qRT-PCR 检测转录本。
Microb Pathog. 2018 Nov;124:316-321. doi: 10.1016/j.micpath.2018.08.062. Epub 2018 Aug 30.
5
Comparative sequence analysis of Mycobacterium leprae and the new leprosy-causing Mycobacterium lepromatosis.麻风分枝杆菌与新发现的致麻风病的利氏麻风分枝杆菌的比较序列分析。
J Bacteriol. 2009 Oct;191(19):6067-74. doi: 10.1128/JB.00762-09. Epub 2009 Jul 24.
6
A phylogenomic study quantifies competing mechanisms for pseudogenization in prokaryotes-The Mycobacterium leprae case.一项基于系统发生基因组学的研究定量评估了原核生物假基因化的竞争机制——以麻风分枝杆菌为例。
PLoS One. 2018 Nov 1;13(11):e0204322. doi: 10.1371/journal.pone.0204322. eCollection 2018.
7
Construction and Analysis of the Complete Genome Sequence of Leprosy Agent Mycobacterium lepromatosis.构建并分析麻风分枝杆菌全基因组序列。
Microbiol Spectr. 2022 Jun 29;10(3):e0169221. doi: 10.1128/spectrum.01692-21. Epub 2022 Apr 25.
8
Mycobacterium leprae's evolution and environmental adaptation.麻风分枝杆菌的进化与环境适应。
Acta Trop. 2019 Sep;197:105041. doi: 10.1016/j.actatropica.2019.105041. Epub 2019 May 30.
9
Insight into the evolution and origin of leprosy bacilli from the genome sequence of Mycobacterium lepromatosis.从麻风分枝杆菌的基因组序列洞察麻风杆菌的进化与起源。
Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4459-64. doi: 10.1073/pnas.1421504112. Epub 2015 Mar 23.
10
Ancient genomes reveal a high diversity of Mycobacterium leprae in medieval Europe.古代基因组揭示了中世纪欧洲麻风分枝杆菌的高度多样性。
PLoS Pathog. 2018 May 10;14(5):e1006997. doi: 10.1371/journal.ppat.1006997. eCollection 2018 May.
引用本文的文献
1
Genetic variability, genotyping, and genomics of Mycobacterium leprae.麻风分枝杆菌的遗传变异性、基因分型和基因组学。
FEMS Microbiol Rev. 2025 Jan 14;49. doi: 10.1093/femsre/fuaf012.
2
Genetic diversity of Mycobacterium leprae: Need to move towards genome-wide approaches.麻风分枝杆菌的遗传多样性：需要向全基因组方法转变。
Indian J Med Res. 2024 Feb 1;159(2):121-129. doi: 10.4103/ijmr.ijmr_2383_22. Epub 2024 Apr 4.
3
Unlocking Opportunities for and .为 和 解锁机会。
ACS Infect Dis. 2024 Feb 9;10(2):251-269. doi: 10.1021/acsinfecdis.3c00371. Epub 2024 Jan 31.
4
Mycobacterial metabolic model development for drug target identification.用于药物靶点识别的分枝杆菌代谢模型开发
GigaByte. 2023 Apr 30;2023:gigabyte80. doi: 10.46471/gigabyte.80. eCollection 2023.
5
Association of the rs2111234, rs3135499, rs8057341 polymorphisms in the NOD2 gene with leprosy: A case-control study in the Norte de Santander, Colombia population.NOD2 基因中 rs2111234、rs3135499、rs8057341 多态性与麻风病的关联：哥伦比亚北桑坦德人群的病例对照研究。
PLoS One. 2023 Mar 6;18(3):e0281553. doi: 10.1371/journal.pone.0281553. eCollection 2023.
6
Pathogenicity and virulence of . 的致病性和毒力。
Virulence. 2022 Dec;13(1):1985-2011. doi: 10.1080/21505594.2022.2141987.
7
Pseudofinder: Detection of Pseudogenes in Prokaryotic Genomes.伪基因查找器：原核基因组中伪基因的检测。
Mol Biol Evol. 2022 Jul 2;39(7). doi: 10.1093/molbev/msac153.
8
Mycobacterium tuberculosis EspK Has Active but Distinct Roles in the Secretion of EsxA and EspB.结核分枝杆菌 EspK 在 EsxA 和 EspB 的分泌中具有活跃但不同的作用。
J Bacteriol. 2022 Apr 19;204(4):e0006022. doi: 10.1128/jb.00060-22. Epub 2022 Mar 22.
9
Algorithm Design for a Cytokine Release Assay of Antigen-Specific In Vitro Stimuli of Circulating Leukocytes to Classify Leprosy Patients and Household Contacts.用于循环白细胞抗原特异性体外刺激的细胞因子释放测定以对麻风病患者和家庭接触者进行分类的算法设计
Open Forum Infect Dis. 2022 Jan 30;9(3):ofac036. doi: 10.1093/ofid/ofac036. eCollection 2022 Mar.
10
Human macrophage polarization in the response to genomic DNA.人类巨噬细胞对基因组DNA反应中的极化
Curr Res Microb Sci. 2020 Nov 26;2:100015. doi: 10.1016/j.crmicr.2020.100015. eCollection 2021 Dec.
本文引用的文献
1
Comments on the History of Leprosy.
Ind Med Gaz. 1942 Nov;77(11):680-685.
2
Detection of Mycobacterium leprae DNA from archaeological skeletal remains in Japan using whole genome amplification and polymerase chain reaction.利用全基因组扩增和聚合酶链反应从日本考古骨骼遗骸中检测麻风分枝杆菌 DNA。
PLoS One. 2010 Aug 26;5(8):e12422. doi: 10.1371/journal.pone.0012422.
3
Global leprosy situation, 2010.2010年全球麻风病疫情
Wkly Epidemiol Rec. 2010 Aug 27;85(35):337-48.
4
Infection during infancy and long incubation period of leprosy suggested in a case of a chimpanzee used for medical research.在一项用于医学研究的黑猩猩案例中，提示了在婴儿期感染和麻风病潜伏期长的情况。
J Clin Microbiol. 2010 Sep;48(9):3432-4. doi: 10.1128/JCM.00017-10. Epub 2010 Jul 14.
5
Mutation rates of spoligotypes and variable numbers of tandem repeat loci in Mycobacterium tuberculosis.结核分枝杆菌 spoligotype 及可变数目串联重复序列位点的突变率。
Infect Genet Evol. 2010 Oct;10(7):1046-51. doi: 10.1016/j.meegid.2010.06.016. Epub 2010 Jul 7.
6
Genotypic analysis of Mycobacterium leprae strains from different regions of India on the basis of rpoT.基于rpoT对来自印度不同地区的麻风分枝杆菌菌株进行基因分型分析。
Indian J Lepr. 2009 Jul-Sep;81(3):119-24.
7
Molecular epidemiology of Mycobacterium leprae as determined by structure-neighbor clustering.麻风分枝杆菌的结构邻居聚类分子流行病学研究。
J Clin Microbiol. 2010 Jun;48(6):1997-2008. doi: 10.1128/JCM.00149-10. Epub 2010 Mar 29.
8
Drug resistance in leprosy.麻风病耐药性。
Jpn J Infect Dis. 2010 Jan;63(1):1-7.
9
Molecular exploration of the first-century Tomb of the Shroud in Akeldama, Jerusalem.阿克伦达玛的第一世纪裹尸布墓穴的分子探索。
PLoS One. 2009 Dec 16;4(12):e8319. doi: 10.1371/journal.pone.0008319.
10
Characterisation of short tandem repeats for genotyping Mycobacterium leprae.用于麻风分枝杆菌基因分型的短串联重复序列的特征分析
Lepr Rev. 2009 Sep;80(3):250-60.
Zotero 插件