Faculty of Medicine, University of New South Wales, NSW, 2052, Australia.
Arthritis Res Ther. 2010;12(6):149. doi: 10.1186/ar3191. Epub 2010 Dec 16.
Investigation of the genetic basis of hyperuricaemia is a subject of intense interest. However, clinical studies commonly include hyperuricaemic patients without distinguishing between 'over-producers' or 'under-excretors' of urate. The statistical power of studies of genetic polymorphisms of genes encoding renal urate transporters is diluted if 'over-producers' of uric acid are included. We propose that lower than normal fractional renal clearance of urate is a better inclusion criterion for these studies. We also propose that a single daytime spot urine sample for calculation of fractional renal clearance of urate should be preferred to calculation from 24-hour urine collections.
高尿酸血症的遗传基础研究是一个热点。然而，临床研究通常包括高尿酸血症患者，但并未区分尿酸“生成过多者”或“排泄过少者”。如果将尿酸“生成过多者”纳入研究，那么对编码肾脏尿酸转运蛋白的基因遗传多态性的研究的统计效力将会受到稀释。我们建议，低于正常的尿酸肾部分清除率是这些研究更好的纳入标准。我们还建议，单次日间尿样用于尿酸肾部分清除率的计算应优于 24 小时尿收集的计算。
