Miao Pei-tian, Tong Zhong-sheng, Hao Chun-fang, Zhang Li
Department of Breast Oncology, Tianjin Medical University Cancer Institute, Tianjin, China.
Zhonghua Yi Xue Za Zhi. 2010 Nov 2;90(40):2848-51.
To analyze the clinical features and survival for patients with metastatic triple negative breast cancer (MTNBC), especially such a metastatic site as brain.
The clinical data and survival status of 120 cases of operable MTNBC treated at our hospital from January 2002 to December 2004 were collected. SPSS 13.0 software was used for statistic treatment. Statistical significance was considered at P < 0.05.
At the time of last follow-up, the median time after metastasis was 22 months. Nine deaths (65.8%) were recorded. In terms of all metastatic sites (initial + subsequent), lung (58.3%), liver (41.7%) and brain (40.8%) were most common sites. The patients with brain metastasis had a worse survival than those with non-brain metastases. Twenty-two (18.3%) patients were found to have brain metastasis at the time of first metastatic presentation. The initial metastatic site in patients with brain metastasis had a worse survival than those with non-brain metastases. The median survival time after metastasis was 8 and 31 months respectively (P = 0.000).
Triple-negative breast cancer is associated with a poor survival after metastases. The patients with brain metastases have a worse survival than those with non-brain metastases. New treatment strategies are needed.
分析转移性三阴性乳腺癌（MTNBC）患者的临床特征及生存情况，尤其是脑转移这一转移部位。
收集2002年1月至2004年12月在我院接受治疗的120例可手术MTNBC患者的临床资料及生存状况。采用SPSS 13.0软件进行统计学处理。P<0.05为差异有统计学意义。
末次随访时，转移后的中位时间为22个月。记录到9例死亡（65.8%）。就所有转移部位（初始+后续）而言，肺（58.3%）、肝（41.7%）和脑（40.8%）是最常见的部位。脑转移患者的生存情况比非脑转移患者差。22例（18.3%）患者在首次出现转移时被发现有脑转移。脑转移患者的初始转移部位的生存情况比非脑转移患者差。转移后的中位生存时间分别为8个月和31个月（P=0.000）。
三阴性乳腺癌转移后生存较差。脑转移患者的生存情况比非脑转移患者差。需要新的治疗策略。
