Shao Hua-jiang, Ma Jian-ting, Yang Xiu-er, Xu Li-ping, Yang Chun-lin
Department of Obstetrics & Gynecology, Yuyao People's Hospital, Yuyao 315400, China.
Zhonghua Yi Xue Za Zhi. 2010 Oct 12;90(37):2616-9.
To investigate the suitable measures of diagnosis and treatment of cesarean scar pregnancy (CSP).
From May 2003 to February 2010, 52 cases were diagnosed as CSP on the basis of the history of cesarean section and the manifestations of pregnancy by transvaginal ultrasound and magnetic resonance imaging (MRI) examination. According to the blood level of β-HCG, 32 patients underwent uterine artery methotrexate perfusion and uterine artery embolization (UAE), 20 cases received a protocol of methotrexate and leucovorin (CF) while UAE or Foley catheter balloon hemostasis was performed for massive vaginal bleeding cases. When β-HCG decreased 80% - 90% and mass blood flow reduced or disappeared, focal resection was administered.
Forty-six cases were diagnosed by transvaginal ultrasound and 6 cases by MRI. On admission, 11 patients with severe vaginal bleeding underwent UAE or Foley catheter hemostasis. Forty patients undergoing curettage had no uterine perforation or rupture with hysteroscopic guidance and laparoscopic monitoring if necessary. Among them, 39 (97.5%) cases were successful. Six cases were directly treated by laparotomy or laparoscopic focal resection and uterine repair. And 6 cases underwent conservative treatment without focal resection. 52 patients were cured successfully without any case of hysterectomy.
Transvaginal ultrasound is the preferred diagnostic method of CSP while MRI is an auxiliary method for diagnosis. The treatment of CSP should be based on blood β-HCG levels and lesion location, size, muscle thickness of surface, the condition of blood supply and vaginal bleeding. Different measures may be selected to kill embryos, stop hemorrhage and resect lesions.
探讨剖宫产瘢痕妊娠(CSP)合适的诊断与治疗措施。
2003年5月至2010年2月,52例患者根据剖宫产史及经阴道超声和磁共振成像(MRI)检查的妊娠表现被诊断为CSP。根据β-HCG血值水平,32例患者接受子宫动脉甲氨蝶呤灌注及子宫动脉栓塞术(UAE),20例患者接受甲氨蝶呤和亚叶酸钙(CF)方案治疗,对于大量阴道出血病例则行UAE或 Foley 导管球囊止血。当β-HCG下降80% - 90%且肿块血流减少或消失时,进行局部切除术。
46例经阴道超声诊断,6例经MRI诊断。入院时,11例严重阴道出血患者接受了UAE或Foley导管止血。40例行刮宫术的患者在必要时经宫腔镜引导及腹腔镜监测,未发生子宫穿孔或破裂。其中,39例(97.5%)成功。6例直接行剖腹手术或腹腔镜局部切除及子宫修复。6例接受保守治疗未行局部切除。52例患者均成功治愈,无1例行子宫切除术。
经阴道超声是CSP的首选诊断方法,而MRI是辅助诊断方法。CSP的治疗应根据血β-HCG水平、病变位置、大小、表面肌层厚度、血供情况及阴道出血情况,选择不同措施杀死胚胎、止血及切除病变。