Division of Dairy Cattle Physiology Division, National Dairy Research Institute, Karnal, Haryana, India.
Anim Reprod Sci. 2011 Jan;123(1-2):5-13. doi: 10.1016/j.anireprosci.2010.11.008. Epub 2010 Nov 25.
Guduchi (Tinospora cordifolia), a medicinal plant used in ayurveda, is well documented for its immunomodulatory properties. Since the crossbred periparturient cow is highly susceptible to various diseases that effectively reduces its reproductive performance postpartum we explored the possibility of enhancing the reproductive performance of crossbred cows by guduchi supplementation peripartum. A total of 15 pregnant Karan Fries cows were selected and divided into two groups: treatment group of 8 cows which were supplemented with guduchi at 60 g/day for 45 days prepartum and 120 g/day for 45 days postpartum and unsupplemented control group of 7 cows. Jugular blood samples were collected from all cows during the periparturient period for analysis of endocrine (progesterone, total estrogens and PGFM), immunological and hematological parameters. Incidence of retention of fetal membranes, endometritis, pyometra and calf mortality were higher in control group of cows in comparison to those recorded in treated group. The guduchi supplemented cows exhibited faster uterine involution (28 days vs. 42 days) and early commencement of cyclicity (37 days vs. 58 days; based on plasma progesterone profiles) in comparison to untreated control group of cows. Mean birth weight of calves from treatment group of cows was significantly higher than those from control group however no significant difference was observed in average daily body weight gain of calves in both the groups. A higher total leukocyte, lymphocyte, neutrophil count along with increased neutrophil lymphocyte ratio was recorded in guduchi supplemented cows in comparison to untreated cows although plasma total antioxidant activity was similar between the two groups. Prepartum plasma progesterone concentration was significantly lowered in the treated group however there was no significant change in peripartum plasma total estrogens and PGFM levels due to guduchi supplementation.
古得奇（Tinospora cordifolia）是一种在阿育吠陀医学中使用的药用植物，其免疫调节特性已有充分的文献记载。由于杂交围产期奶牛易患多种疾病，这会有效降低其产后繁殖性能，因此我们探索了在围产期用古得奇补充剂来提高杂交奶牛繁殖性能的可能性。总共选择了 15 头怀孕的卡兰弗里茨奶牛，并将它们分为两组：治疗组 8 头，在产前 45 天每天补充 60 克，产后 45 天每天补充 120 克；未补充的对照组 7 头。在围产期期间，从所有奶牛采集颈静脉血样，用于分析内分泌（孕酮、总雌激素和 PGFM）、免疫和血液学参数。与治疗组相比，对照组奶牛的胎衣滞留、子宫内膜炎、子宫积脓和犊牛死亡率较高。与未治疗的对照组奶牛相比，用古得奇补充剂的奶牛子宫复旧更快（28 天对 42 天），并且更早开始周期性（37 天对 58 天；基于血浆孕酮谱）。治疗组奶牛的犊牛平均出生体重明显高于对照组，但两组犊牛的平均日增重无显著差异。与未治疗的奶牛相比，用古得奇补充剂的奶牛总白细胞、淋巴细胞和中性粒细胞计数较高，中性粒细胞与淋巴细胞的比例也较高，尽管两组的血浆总抗氧化活性相似。治疗组奶牛的产前血浆孕酮浓度显著降低，但由于古得奇的补充，围产期血浆总雌激素和 PGFM 水平没有显著变化。
