Malvicini Mariana, Puchulo Guillermo, Matar Pablo, Mazzolini Guillermo
Laboratorio de Terapia Génica, Facultad de Ciencias Biomédicas, Universidad Austral, Buenos Aires, Argentina.
Medicina (B Aires). 2010;70(6):565-70.
Increasing evidence indicates that the immune system is involved in the control of tumor progression. Effective antitumor immune response depends on the interaction between several components of the immune system, including antigen-presenting cells and different T cell subsets. However, tumor cells develop a number of mechanisms to escape recognition and elimination by the immune system. In this review we discuss these mechanisms and address possible therapeutic approaches to overcome the immune suppression generated by tumors.
越来越多的证据表明，免疫系统参与肿瘤进展的控制。有效的抗肿瘤免疫反应取决于免疫系统的几个组成部分之间的相互作用，包括抗原呈递细胞和不同的T细胞亚群。然而，肿瘤细胞会发展出多种机制来逃避免疫系统的识别和清除。在这篇综述中，我们讨论这些机制，并探讨克服肿瘤产生的免疫抑制的可能治疗方法。
